Immune modulation of some autoimmune diseases: the critical role of macrophages and neutrophils in the innate and adaptive immunity

Journal of Translational Medicine

Review

Paula Giselle Czaikoski¹  Priscilla Aparecida Tártari Pereira²  Rafaelli de Souza Gomes³  Kely Campos Navegantes³  Carolina Heitmann Mares Azevedo³  Marta Chagas Monteiro³ 

[1] College of Pharmacy, Guairacá Faculty-PR, Guarapuava, PR, Brazil;Department of Clinical, Bromatological and Toxicological Analysis, Ribeirão Preto Pharmaceutical Sciences School, USP-SP, Ribeirão Preto, SP, Brazil;Pharmaceutical Science Post-Graduation Program, Health Science Institute, Federal University of Pará/UFPA, 66075900, Belém, PA, Brazil;

关键词: Macrophages;    Neutrophils;    Autoimmunity;    Autoimmune disease;    Inflammation;   

DOI  :  10.1186/s12967-017-1141-8

 received in 2016-11-18, accepted in 2017-02-03,  发布年份 2017

来源: Springer

【 摘 要 】

Macrophages and neutrophils are key components involved in the regulation of numerous chronic inflammatory diseases, infectious disorders, and especially certain autoimmune disease. However, little is known regarding the contribution of these cells to the pathogenesis of autoimmune disorders. Recent studies have aimed to clarify certain important factors affecting the immunogenicity of these cells, including the type and dose of antigen, the microenvironment of the cell-antigen encounter, and the number, subset, and phenotype of these cells, which can prevent or induce autoimmune responses. This review highlights the role of macrophage subsets and neutrophils in injured tissues, supporting their cooperation during the pathogenesis of certain autoimmune diseases.

【 授权许可】

CC BY   
© The Author(s) 2017

【 图 表 】

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