Gestational malaria associated to Plasmodium vivax and Plasmodium falciparum placental mixed-infection followed by foetal loss: a case report from an unstable transmission area in Brazil

Malaria Journal

Case Report

Fernanda Franzin¹  Juliana A Leite¹  Fabio TM Costa¹  Gustavo B Gregoracci¹  Bruna O Carvalho²  Marcus VG Lacerda³  Sergio LB Luz⁴  Joycenéa S Matsuda⁴  Paulo A Nogueira⁴  Patrícia P Orlandi⁴  Flor E Martinez-Espinosa⁵ 

[1] Departamento de Genética, Evolução e Bioagentes, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil;Departamento de Genética, Evolução e Bioagentes, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil;Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Manaus, AM, Brazil;Fundação de Medicina Tropical do Amazonas (FMT-AM), Manaus, AM, Brazil;Universidade do Estado do Amazonas (UEA), Manaus, AM, Brazil;Centro Universitário Nilton Lins, Manaus, AM, Brazil;Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Manaus, AM, Brazil;Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Manaus, AM, Brazil;Fundação de Medicina Tropical do Amazonas (FMT-AM), Manaus, AM, Brazil;

关键词: Malaria;    Placental Tissue;    Vivax Malaria;    Vivax Infection;    Plasmodial Infection;   

DOI  :  10.1186/1475-2875-10-178

 received in 2010-11-26, accepted in 2011-06-27,  发布年份 2011

来源: Springer

【 摘 要 】

Gestational malaria is a multi-factorial syndrome leading to poor outcomes for both the mother and foetus. Although an unusual increasing in the number of hospitalizations caused by Plasmodium vivax has been reported in Brazil, mortality is rarely observed. This is a report of a gestational malaria case that occurred in the city of Manaus (Amazonas State, Brazil) and resulted in foetal loss. The patient presented placental mixed-infection by Plasmodium vivax and Plasmodium falciparum after diagnosis by nested-PCR, however microscopic analysis failed to detect P. falciparum in the peripheral blood. Furthermore, as the patient did not receive proper treatment for P. falciparum and hospitalization occurred soon after drug treatment, it seems that P. falciparum pathology was modulated by the concurrent presence of P. vivax. Collectively, this case confirms the tropism towards the placenta by both of these species of parasites, reinforces the notion that co-existence of distinct malaria parasites interferes on diseases' outcomes, and opens discussions regarding diagnostic methods, malaria treatment during pregnancy and prenatal care for women living in unstable transmission areas of malaria, such as the Brazilian Amazon.

【 授权许可】

Unknown   
© Carvalho et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.