Transcriptomics of malaria host-pathogen interactions in primates

Malaria;Transcriptomics;RNA-seq;Functional genomics;Pyrimethamine;Plasmodium cynomolgi;Macaca mulatta

Lee, Kevin Joseph ; Gibson, Greg Biology Galinski, Mary Jordan, King Choi, Jung McDonald, John ; Gibson, Greg

University:Georgia Institute of Technology

Department:Biology

关键词: Malaria;    Transcriptomics;    RNA-seq;    Functional genomics;    Pyrimethamine;    Plasmodium cynomolgi;    Macaca mulatta;   

Others  :  https://smartech.gatech.edu/bitstream/1853/54264/1/LEE-DISSERTATION-2014.pdf

美国|英语

来源: SMARTech Repository

【 摘 要 】

Malaria is a pernicious disease that has greatly impacted and continues to affect the human population.While much research has been performed to understand the underlying nature of this disease, gaps in the knowledge-base persist.In order to address these deficiencies, a multi-disciplinary, multi-institutional project has been funded to study the systems biology of the host pathogen interaction during malaria infection in both humans and non-human primates.In the course of investigating the transcriptome during two 100-day experiments in Macaca mulatta, this work elucidated many of the underlying molecular pathways of the host and parasite that are affected by antimalarial drugs, as well as through host-pathogen interactions.The malaria-disease-related host pathways are related to, not surprisingly, immune-associated signalling and hematopoesis, and the altered parasite pathways demonstrate an association between disease severity and parasite life stage abundance.Continuing integration of this research with other data-types collected during the course of these experiments will improve our understanding of malaria systems biology and improve targeted malaria therapies.