Oxidative stress and ROS-mediated cellular events in RSV infection: potential protective roles of antioxidants

Virology Journal

Review

Yujun Nie¹  Bin Zhu¹  Xue Yang¹  Fei Zhan¹  Xue Liu¹ 

[1] Department of Pediatrics, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, 441021, Xiangyang, Hubei, China;

关键词: Respiratory syncytial virus;    Oxidative stress;    Reactive oxygen species;    Nrf2;    NLRP3;    NETs;    HMGB1;   

DOI  :  10.1186/s12985-023-02194-w

 received in 2023-07-04, accepted in 2023-09-27,  发布年份 2023

来源: Springer

【 摘 要 】

Respiratory syncytial virus (RSV), a member of the Pneumoviridae family, can cause severe acute lower respiratory tract infection in infants, young children, immunocompromised individuals and elderly people. RSV is associated with an augmented innate immune response, enhanced secretion of inflammatory cytokines, and necrosis of infected cells. Oxidative stress, which is mainly characterized as an imbalance in the production of reactive oxygen species (ROS) and antioxidant responses, interacts with all the pathophysiologic processes above and is receiving increasing attention in RSV infection. A gradual accumulation of evidence indicates that ROS overproduction plays an important role in the pathogenesis of severe RSV infection and serves as a major factor in pulmonary inflammation and tissue damage. Thus, antioxidants seem to be an effective treatment for severe RSV infection. This article mainly reviews the information on oxidative stress and ROS-mediated cellular events during RSV infection for the first time.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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