Role of Nrf2 in bone metabolism

Journal of Biomedical Science

Jiliang Li²  Yang Yang¹  Ai-Hua Xu¹  Yong-Xin Sun¹ 

[1] Department of Rehabilitation, The First Affiliated Hospital, China Medical University, No.155,North Nanjing Street, Heping District, Shenyang 110001, China;Department of Biology, Indiana University Purdue University Indianapolis, Indianapolis 46202, IN, USA

关键词: Reactive oxygen species;    Osteoclast;    Osteoblast;    Osteoporosis;    Nrf2;   

Others  :  1235093
DOI  :  10.1186/s12929-015-0212-5

 received in 2015-05-21, accepted in 2015-10-16,  发布年份 2015

【 摘 要 】

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor expressed in many cell types, including osteoblasts, osteocytes, and osteoclasts. Nrf2 has been considered a master regulator of cytoprotective genes against oxidative and chemical insults. The lack of Nrf2 can induce pathologies in multiple organs. Nrf2 deficiency promotes osteoclast differentiation and osteoclast activity, which leads to an increase in bone resorption. The role of Nrf2 in osteoblast differentiation and osteoblast activity is more complex. Nrf2 mediates anabolic effects within an ideal range. Nrf2 deletion suppresses load induced bone formation and delays fracture healing. Overall, Nrf2 plays an important role in the regulation of bone homeostasis in bone cells.

【 授权许可】

   
2015 Sun et al.

【 图 表 】

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