Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation

Molecular Cancer

Review

Ali H. Amin¹  Renzon Daniel Cosme Pecho²  Ahmed H. Ismail³  Mabrouk A. Abo-Zaid³  Devendra Pratap Rao⁴  Natrayan Lakshmaiya⁵  Reza Akhavan-Sigari⁶  Manimaran Vasanthan⁷  Tamilanban Thamaraikani⁸  Narayanan Jayasankar⁸  Omer Qutaiba B. Allela⁹  Ayesha Amajd^1,10  Mohamed J. Saadh^1,11  Patrik Viktor^1,12  Matin Chehelgerdi^1,13  Mohammad Chehelgerdi^1,13  Roxana Yolanda Castillo-Acobo^1,14 

[1] Deanship of Scientific Research, Umm Al-Qura University, 21955, Makkah, Saudi Arabia;Department of Biochemistry, Universidad San Ignacio de Loyola (USIL), Lima, Peru;Department of Biology, College of Science, Jazan University, 82817, Jazan, Saudi Arabia;Department of Chemistry, Coordination Chemistry Laboratory, Dayanand Anglo-Vedic (PG) College, Kanpur-208001, U.P, India;Department of Mechanical Engineering, Saveetha School of Engineering, SIMATS, Chennai, Tamil Nadu, India;Department of Neurosurgery, University Medical Center, Tuebingen, Germany;Department of Health Care Management and Clinical Research, Collegium Humanum Warsaw Management University Warsaw, Warsaw, Poland;Department of Pharmaceutics, SRM Institute of Science and Technology, SRM College Of Pharmacy, Chengalpattu District, 603203, Kattankulathur, Tamil Nadu, India;Department of Pharmacology, SRM Institute of Science and Technology, SRM College Of Pharmacy, Chengalpattu District, 603203, Kattankulathur, Tamil Nadu, India;Department of Pharmacy, Al-Noor University College, Nineveh, Iraq;Faculty of Organization and Management, Silesian University of Technology, 44-100, Gliwice, Poland;Department of Mechanical Engineering, CEMMPRE, University of Coimbra, Polo II, 3030-788, Coimbra, Portugal;Faculty of Pharmacy, Middle East University, 11831, Amman, Jordan;Keleti Károly Faculty of Business and Management, Óbuda University, Tavaszmező U. 15-17, 1084, Budapest, Hungary;Novin Genome (NG) Institute, Research and Development Center for Biotechnology, Shahrekord, Chaharmahal and Bakhtiari, Iran;Young Researchers and Elite Club, Shahrekord Branch, Islamic Azad University, Shahrekord, Chaharmahal and Bakhtiari, Iran;Universidad Nacional de San Agustin de Arequipa, Arequipa, Peru;

关键词: Nanotechnology;    Cancer detection;    Cancer treatment;    Nanoscale targeting techniques;    Protein engineering;    Materials science;    Nanocarriers;    Medicinal purposes;    Human trials;   

DOI  :  10.1186/s12943-023-01865-0

 received in 2023-07-02, accepted in 2023-09-21,  发布年份 2023

来源: Springer

【 摘 要 】

The use of nanotechnology has the potential to revolutionize the detection and treatment of cancer. Developments in protein engineering and materials science have led to the emergence of new nanoscale targeting techniques, which offer renewed hope for cancer patients. While several nanocarriers for medicinal purposes have been approved for human trials, only a few have been authorized for clinical use in targeting cancer cells. In this review, we analyze some of the authorized formulations and discuss the challenges of translating findings from the lab to the clinic. This study highlights the various nanocarriers and compounds that can be used for selective tumor targeting and the inherent difficulties in cancer therapy. Nanotechnology provides a promising platform for improving cancer detection and treatment in the future, but further research is needed to overcome the current limitations in clinical translation.Graphical Abstract

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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