Photodynamic immunotherapy of cancers based on nanotechnology: recent advances and future challenges

Journal of Nanobiotechnology

Guanhua Li¹  Qiwen Wang²  Xiaofeng Jiang²  Xinqiang Wu²  Dawei Zhang²  Ping Xue²  Zhaoyuan Liu²  Liangqi Cao²  Wenting Li³  Han Zhang⁴  Zhongjian Xie⁴ 

[1] Department of Cardiovascular Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, Guangdong, China;Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Guangzhou Medical University, 510260, Guangzhou, China;Department of Traditional Chinese Medicine, The Second Affiliated Hospital of Guangzhou Medical University, 510260, Guangzhou, China;Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Collaborative Innovation Centre for Optoelectronic Science & Technology, Institute of Microscale Optoelectronics, Shenzhen University, 518060, Shenzhen, China;College of Physics and Optoelectronic Engineering, Shenzhen University, 518060, Shenzhen, China;Shenzhen Key Laboratory of Micro-Nano Photonic Information Technology, Guangdong Laboratory of Artificial Intelligence and Digital Economy (SZ), Shenzhen University, 518060, Shenzhen, China;

关键词: Photodynamic therapy;    Nanotechnology;    Immunotherapy;    Cancer treatment;   

DOI  :  10.1186/s12951-021-00903-7

来源: Springer

【 摘 要 】

Photodynamic therapy (PDT) is a non-invasive or minimally-invasive treatment which applies photosensitizers (PSs) to create reactive oxygen species (ROS) exposed to light trigger to destroy cancer cells. PDT can activate host anti-tumor immune responses but not powerful enough to kill metastatic tumors. Because of its carrier advantage, imaging, and therapeutic function together with enhanced permeability and retention (EPR) effect, nano-materials have already been used in photo-immunotherapy. Herein, photodynamic immunotherapy (PDIT) based on nanotechnology seems to be a hopeful new form of cancer therapy. In this article, we firstly summarize the recent development in photodynamic immunotherapy based on nanotechnology.

【 授权许可】

CC BY