Nanomaterials based biosensors for cancer biomarker detection

India-Japan Expert Group Meeting on Biomolecular Electronics & Organic Nanotechnology for Environment Preservation

物理学;生物科学;生态环境科学

Malhotra, Bansi D.^1 ; Kumar, Saurabh^1 ; Pandey, Chandra Mouli^1

Nanobioelectronics Laboratory, Department of Biotechnology, Delhi Technological University, Delhi

110042, India^1

关键词: Cancer biomarker detections;    Cancer biomarkers;    Cancer detection;    Conducting papers;    Molecular diagnostics;    Molecular signatures;    Post-translational modifications;    Protein profiles;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/704/1/012011/pdf
DOI  :  10.1088/1742-6596/704/1/012011

来源: IOP

【 摘 要 】

Biosensors have enormous potential to contribute to the evolution of new molecular diagnostic techniques for patients suffering with cancerous diseases. A major obstacle preventing faster development of biosensors pertains to the fact that cancer is a highly complex set of diseases. The oncologists currently rely on a few biomarkers and histological characterization of tumors. Some of the signatures include epigenetic and genetic markers, protein profiles, changes in gene expression, and post-translational modifications of proteins. These molecular signatures offer new opportunities for development of biosensors for cancer detection. In this context, conducting paper has recently been found to play an important role towards the fabrication of a biosensor for cancer biomarker detection. In this paper we will focus on results of some of the recent studies obtained in our laboratories relating to fabrication and application of nanomaterial modified paper based biosensors for cancer biomarker detection.