Radiopharmaceuticals for SPECT Cancer Detection

8th International Scientific Conference "Issues of Physics and Technology in Science, Industry and Medicine"

物理学;工业技术;医药卫生

Chernov, V.I.^1,2 ; Medvedeva, A.A.^1,2 ; Zelchan, R.V.^1,2 ; Sinilkin, I.G.^1,2 ; Stasyuk, E.S.^2 ; Larionova, L.A.^2 ; Slonimskaya, E.M.^1 ; Choynzonov, E.L.^1

Tomsk Cancer Research Institute, Tomsk, Russia^1

National Research Tomsk Polytechnic University, Tomsk, Russia^2

关键词: Axillary lymph nodes;    Breast Cancer;    Breast lesion;    Breast tumor;    Cancer detection;    Hypopharyngeal cancer;    Imaging method;    Lymph node metastasis;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/135/1/012008/pdf
DOI  :  10.1088/1757-899X/135/1/012008

来源: IOP

【 摘 要 】

The purpose of the study was to assess the efficacy of single photon emission computed tomography (SPECT) with199Tl and99mTc-MIBI in the detection of breast, laryngeal and hypopharyngeal cancers. Materials and Methods: a total of 220 patients were included into the study. Of them, there were 120 patients with breast lesions (100 patients with breast cancer and 20 patients with benign breast tumors) and '00 patients with laryngeal/hypopharyngeal diseases (80 patients with laryngeal/hypopharyngeal cancer and 20 patients with benign laryngeal/hypopharyngeal lesions). Results: no abnormal199Tl uptake was seen in all patients with benign breast and laryngeal lesions, indicating a 100% specificity of199Tl SPECT. In breast cancer patients, increased199Tl uptake in the breast was visualized in 94.8% patients,99mTc-MIBI in 93.4% patients. Increased199Tl uptake in axillary lymph nodes was detected in 60% patients and99mTc-MIBI in 93.1% patients. In patients with laryngeal/hypopharyngeal cancer, sensitivity of SPECT with199Tl and99mTc-MIBI were 95%. The199Tl SPECT sensitivity in identification of regional lymph node metastases in patients with laryngeal/hypopharyngeal cancer was 75% and the99mTc-MIBI SPECT sensitivity was 17%. Conclusion: the data obtained show that SPECT with199Tl and99mTc-MIBI can be used as one of the additional imaging methods in detection of tumors.