Antibacterial activity of statins: a comparative study of Atorvastatin, Simvastatin, and Rosuvastatin

Annals of Clinical Microbiology and Antimicrobials

Research

Ziad Alnasser¹  Nizar Mhaidat²  Karem Alzoubi²  Sayer Al-azzam²  Majed Masadeh² 

[1] Faculty of Medicine, Jordan University of Science & Technology, 22110, Irbid, Jordan;Faculty of Pharmacy, Jordan University of Science & Technology, 22110, Irbid, Jordan;

关键词: Antimicrobial activity;    Statins;    Atorvastatin;    Simvastatin;    Rosuvastatin;   

DOI  :  10.1186/1476-0711-11-13

 received in 2012-02-19, accepted in 2012-05-07,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundStatins have several effects beyond their well-known antihyperlipidemic activity, which include immunomodulatory, antioxidative and anticoagulant effects. In this study, we have tested the possible antimicrobial activity of statins against a range of standard bacterial strains and bacterial clinical isolates.MethodsMinimum inhibitory concentrations (MIC) values were evaluated and compared among three members of the statins drug (atorvastatin, simvastatin, and rosuvastatin).ResultsIt was revealed that statins are able to induce variable degrees of antibacterial activity with atorvastatin, and simvastatin being the more potent than rosuvastatin. Methicillin-sensitive staphylococcus aureus (MSSA), methicillin-resistant staphylococcus aureus (MRSA), vancomycin-susceptible enterococci (VSE), vancomycin-resistant enterococcus (VRE), acinetobacter baumannii, staphylococcus epidermidis, and enterobacter aerogenes, were more sensitive to both atorvastatin, and simvastatin compared to rosuvastatin. On the other hand, escherichia coli, proteus mirabilis, and enterobacter cloacae were more sensitive to atorvastatin compared to both simvastatin and rosuvastatin. Furthermore, most clinical isolates were less sensitive to statins compared to their corresponding standard strains.ConclusionOur findings might raise the possibility of a potentially important antibacterial class effect for statins especially, atorvastatin and simvastatin.

【 授权许可】

CC BY   
© Masadeh et al.; licensee BioMed Central Ltd. 2012