Statin use and risk of depression: a Swedish national cohort study

BMC Psychiatry

Xinjun Li²  Kristina Sundquist³  Jan Sundquist³  Lana J Williams¹  Michael Berk¹  Cassie Redlich² 

[1] Department of Psychiatry, The University of Melbourne, Parkville, Australia;Center for Primary Health Care Research, Lund University, Lund, Sweden;Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, California, USA

关键词: Oxidative stress;    Inflammation;    Aetiology;    Depression;    Simvastatin;    Atorvastatin;    Statins;   

Others  :  1091573
DOI  :  10.1186/s12888-014-0348-y

 received in 2013-11-21, accepted in 2014-11-20,  发布年份 2014

【 摘 要 】

Background

Statin medications, used to prevent heart disease by reducing cholesterol, also reduce inflammation and protect against oxidative damage. As inflammation and oxidative stress occur in depression, there is interest in their potential to reduce depression risk. We investigated whether use of statin medications was associated with a change in the risk of developing depression in a very large Swedish national cohort (n = 4,607,990).

Methods

National register data for adults ≥40yr was analyzed to obtain information about depression diagnoses and prescriptions of statin medications between 2006 and 2008. Associations were tested using logistic regression.

Results

Use of any statin was shown to reduce the odds of depression by 8% compared to individuals not using statin medications (OR = 0.92, 95% CI, 0.89-0.96; p < 0.001). Simvastatin had a protective effect (OR = 0.93, 95% CI, 0.89-0.97; p = 0.001), whereas atorvastatin was associated with increased risk of depression (OR = 1.11, 95% CI, 1.01-1.22; p = 0.032). There was a stepwise decrease in odds ratio with increasing age (OR ≥ 40 years = 0.95, OR ≥ 50 years = 0.91, OR ≥ 60 years = 0.85, OR ≥ 70 years = 0.81).

Conclusions

The use of any statin was associated with a reduction in risk of depression in individuals over the age of 40. Clarification of the strength of these protective effects, the clinical relevance of these effects and determination of which statins are most effective is needed.

【 授权许可】

   
2014 Redlich et al.; licensee BioMed Central Ltd.

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