Effects of HIV-1-induced CD1c and CD1d modulation and endogenous lipid presentation on CD1c-restricted T-cell activation

BMC Immunology

Research Article

Rajakumar Mandraju¹  Jordana GA Coelho-dos-Reis¹  Moriya Tsuji²  Halonna Kelly³ 

[1] HIV and Malaria Vaccine Program, Aaron Diamond AIDS Research Center, Affiliate of The Rockefeller University, 455 First Avenue, 10016, New York, NY, USA;HIV and Malaria Vaccine Program, Aaron Diamond AIDS Research Center, Affiliate of The Rockefeller University, 455 First Avenue, 10016, New York, NY, USA;Department of Medical Parasitology, New York University School of Medicine, 341 East 25th Street, 10010, New York, NY, USA;HIV and Malaria Vaccine Program, Aaron Diamond AIDS Research Center, Affiliate of The Rockefeller University, 455 First Avenue, 10016, New York, NY, USA;Department of Medical Parasitology, New York University School of Medicine, 341 East 25th Street, 10010, New York, NY, USA;Basic Immunology Branch, Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 20892, Bethesda, MD, USA;

关键词: CD1c;    Phosphatidylcholine;    Cholesterol;    T cell;    HIV-1;    Vpu;   

DOI  :  10.1186/1471-2172-14-4

 received in 2012-08-31, accepted in 2013-01-16,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundIt has been shown that human immunodeficiency virus (HIV)-1 infection induces the production of endogenous lipids required for effective viral production, and the cluster of differentiation (CD)1 molecule CD1d is downregulated by HIV-1 infection. However, the role of endogenous lipid presentation and the implications of CD1 downregulation by HIV-1 infection have not yet been characterized.ResultsIn this study, we observed downregulation of both CD1c and CD1d expression through a Vpu-dependent and Nef-independent mechanism, and the concomitant HIV-1-induced production of host cholesterol decreased the extent of CD1c and CD1d modulation. While the modest downregulation of CD1c by HIV-1 infection decreased the ability of CD1c-restricted T cells to respond and secrete interferon-γ, the cholesterol upregulation in the same cells by HIV-1 infection appears to limit the downregulation of CD1c.ConclusionsThe two conflicting HIV-1-mediated changes in CD1c expression appear to minimize the modulation of CD1c expression, thus leading the host to maintain a CD1c-restricted T-cell response against HIV-1.

【 授权许可】

Unknown   
© Kelly et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.