BMC Immunology | |
Effects of HIV-1-induced CD1c and CD1d modulation and endogenous lipid presentation on CD1c-restricted T-cell activation | |
Moriya Tsuji1  Jordana GA Coelho-dos-Reis2  Rajakumar Mandraju2  Halonna Kelly3  | |
[1] Department of Medical Parasitology, New York University School of Medicine, 341 East 25th Street, New York, NY, 10010, USA;HIV and Malaria Vaccine Program, Aaron Diamond AIDS Research Center, Affiliate of The Rockefeller University, 455 First Avenue, New York, NY, 10016, USA;Current Address: Basic Immunology Branch, Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA | |
关键词: Vpu; HIV-1; T cell; Cholesterol; Phosphatidylcholine; CD1c; | |
Others : 1077845 DOI : 10.1186/1471-2172-14-4 |
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received in 2012-08-31, accepted in 2013-01-16, 发布年份 2013 | |
【 摘 要 】
Background
It has been shown that human immunodeficiency virus (HIV)-1 infection induces the production of endogenous lipids required for effective viral production, and the cluster of differentiation (CD)1 molecule CD1d is downregulated by HIV-1 infection. However, the role of endogenous lipid presentation and the implications of CD1 downregulation by HIV-1 infection have not yet been characterized.
Results
In this study, we observed downregulation of both CD1c and CD1d expression through a Vpu-dependent and Nef-independent mechanism, and the concomitant HIV-1-induced production of host cholesterol decreased the extent of CD1c and CD1d modulation. While the modest downregulation of CD1c by HIV-1 infection decreased the ability of CD1c-restricted T cells to respond and secrete interferon-γ, the cholesterol upregulation in the same cells by HIV-1 infection appears to limit the downregulation of CD1c.
Conclusions
The two conflicting HIV-1-mediated changes in CD1c expression appear to minimize the modulation of CD1c expression, thus leading the host to maintain a CD1c-restricted T-cell response against HIV-1.
【 授权许可】
2013 Kelly et al.; licensee BioMed Central Ltd.
【 预 览 】
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