BMC Cardiovascular Disorders | |
Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus | |
Research Article | |
Takayoshi Yamaki1  Masayoshi Oikawa1  Shu-ichi Saitoh1  Akiomi Yoshihisa1  Hitoshi Suzuki1  Hiroyuki Kunii1  Takamasa Sato1  Satoshi Suzuki1  Tetsuro Yokokawa1  Kazuhiko Nakazato1  Yasuchika Takeishi1  Atsushi Kobayashi1  Takafumi Ishida1  Akito Shimouchi2  | |
[1] Department of Cardiovascular Medicine, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Fukushima, Japan;Department of Lifelong Sports for Health Biochemical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Aichi, Japan; | |
关键词: Acetone; Breath analysis; Heart failure; Diabetes mellitus; | |
DOI : 10.1186/s12872-017-0713-0 | |
received in 2017-05-21, accepted in 2017-11-09, 发布年份 2017 | |
来源: Springer | |
【 摘 要 】
BackgroundBreath acetone is a noninvasive biomarker of heart failure; however, its significance in heart failure patients with diabetes mellitus has yet to be clarified. The objective of this study is to investigate whether exhaled acetone concentration is a noninvasive biomarker in heart failure patients with diabetes mellitus.MethodsThis study prospectively included 35 diabetic patients with stage C heart failure and 20 diabetic patients with or at risk of heart failure (stage A or B). Exhaled breath was collected after an overnight fast.ResultsThe stage C group had significantly higher brain natriuretic peptide levels, larger left ventricular diameter, lower left ventricular ejection fraction, and more frequent use of β-blocker, compared with the stage A or B group. The stage C group had higher exhaled acetone concentrations than the stage A or B group (p = 0.013). Exhaled acetone concentration was correlated with total ketone bodies (r = 0.588, p < 0.001) and brain natriuretic peptide (r = 0.415, p = 0.002).ConclusionStage C heart failure patients with diabetes mellitus have elevated exhaled acetone concentrations. Exhaled acetone concentration could be a noninvasive biomarker in heart failure patients with diabetes mellitus.
【 授权许可】
CC BY
© The Author(s). 2017
【 预 览 】
Files | Size | Format | View |
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RO202311100419911ZK.pdf | 593KB | download |
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