Diabetes, hypertension, and cardiovascular disease development

Journal of Translational Medicine

James Cheng-Chung Wei¹  Chii-Min Hwu²  Fu-Shun Yen³  Chih-Cheng Hsu⁴  Lu-Ting Chiu⁵ 

[1] Department of Allergy, Immunology & Rheumatology, Chung Shan Medical University Hospital, No. 110, Sec. 1, Jianguo N. Rd., South District, 40201, Taichung City, Taiwan;Institute of Medicine, Chung Shan Medical University, No. 110, Sec. 1, Jianguo N. Rd., South District, 40201, Taichung City, Taiwan;Graduate Institute of Integrated Medicine, China Medical University, No.91, Hsueh-Shih Road, 40402, Taichung, Taiwan;Department of Medicine, National Yang-Ming Chiao Tung University School of Medicine, No.155, Sec.2, Linong Street, 11221, Taipei, Taiwan;Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Road, Beitou District, 11217, Taipei, Taiwan;Dr. Yen’s Clinic, No. 15, Shanying Road, Gueishan District, 33354, Taoyuan, Taiwan;Institute of Population Health Sciences, National Health Research Institutes, 35 Keyan Road, 35053, Zhunan, Miaoli County, Taiwan;Department of Health Services Administration, China Medical University, No.91, Hsueh-Shih Road, 40402, Taichung, Taiwan;Department of Family Medicine, Min-Sheng General Hospital, 168 ChingKuo Road, 33044, Taoyuan, Taiwan;Management Office for Health Data, China Medical University Hospital, 3F., No.373-2, Jianxing Road, 40459, Taichung, Taiwan;College of Medicine, China Medical University, No. 110, Sec. 1, Jianguo N. Rd., South District, 40201, Taichung City, Taiwan;

关键词: Diabetes mellitus;    Hypertension;    Coronary artery disease;    Stroke;    Heart failure;   

DOI  :  10.1186/s12967-021-03217-2

来源: Springer

【 摘 要 】

BackgroundWe aimed to compare cardiovascular risks among participants with T2DM with and without subsequent HTN and participants with HTN with and without subsequent T2DM.MethodsFrom January 1, 2000, to December 31, 2018, we identified 16,236 matched pairs of T2DM participants with and without HTN (T2DM cohorts), 53,509 pairs of HTN participants with and without T2DM (HTN cohorts), and 21,158 pairs of comorbid HTN and T2DM participants with T2DM history or HTN history (comorbid cohorts) from Taiwan’s National Health Insurance Research Database. Cox proportional-hazard models were used to calculate the risk of cardiovascular disease.ResultsThe mean follow-up time of this study was 6.75 years. Mean incident rates of coronary artery disease for T2DM cohorts, HTN cohorts, and comorbid cohorts were 16.80, 23.18, and 31.53 per 1000 person-years, respectively. The adjusted hazard ratios (HRs) (95% confidence intervals [95% CIs]) for incident coronary artery disease, stroke, and heart failure in T2DM participants with versus without HTN were 2.22 (2.07–2.37), 1.19 (1.16–1.23), and 0.92 (0.82–1.02), respectively; the adjusted HRs for HTN participants with versus without T2DM were 1.69 (1.55–1.84), 1.25 (1.21–1.30), and 0.98 (0.93–1.05), respectively; the adjusted HRs for comorbid T2DM and HTN participants with previous T2DM versus previous HTN were 2.78 (2.37–3.27), 1.20 (1.13–1.28), and 0.95 (0.88–1.03), respectively.ConclusionsThis nationwide cohort study demonstrated that both T2DM with subsequent HTN and HTN with subsequent diabetes were associated with higher cardiovascular disease risks.

【 授权许可】

CC BY