Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus

BMC Cardiovascular Disorders

Research Article

Takayoshi Yamaki¹  Masayoshi Oikawa¹  Shu-ichi Saitoh¹  Akiomi Yoshihisa¹  Hitoshi Suzuki¹  Hiroyuki Kunii¹  Takamasa Sato¹  Satoshi Suzuki¹  Tetsuro Yokokawa¹  Kazuhiko Nakazato¹  Yasuchika Takeishi¹  Atsushi Kobayashi¹  Takafumi Ishida¹  Akito Shimouchi² 

[1] Department of Cardiovascular Medicine, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Fukushima, Japan;Department of Lifelong Sports for Health Biochemical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Aichi, Japan;

关键词: Acetone;    Breath analysis;    Heart failure;    Diabetes mellitus;   

DOI  :  10.1186/s12872-017-0713-0

 received in 2017-05-21, accepted in 2017-11-09,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundBreath acetone is a noninvasive biomarker of heart failure; however, its significance in heart failure patients with diabetes mellitus has yet to be clarified. The objective of this study is to investigate whether exhaled acetone concentration is a noninvasive biomarker in heart failure patients with diabetes mellitus.MethodsThis study prospectively included 35 diabetic patients with stage C heart failure and 20 diabetic patients with or at risk of heart failure (stage A or B). Exhaled breath was collected after an overnight fast.ResultsThe stage C group had significantly higher brain natriuretic peptide levels, larger left ventricular diameter, lower left ventricular ejection fraction, and more frequent use of β-blocker, compared with the stage A or B group. The stage C group had higher exhaled acetone concentrations than the stage A or B group (p = 0.013). Exhaled acetone concentration was correlated with total ketone bodies (r = 0.588, p < 0.001) and brain natriuretic peptide (r = 0.415, p = 0.002).ConclusionStage C heart failure patients with diabetes mellitus have elevated exhaled acetone concentrations. Exhaled acetone concentration could be a noninvasive biomarker in heart failure patients with diabetes mellitus.

【 授权许可】

CC BY   
© The Author(s). 2017