IgG antibodies to synthetic GPI are biomarkers of immune-status to both Plasmodium falciparum and Plasmodium vivax malaria in young children

Malaria Journal

Research

Amandine Carmagnac¹  Benson Kiniboro²  Enmoore Lin²  Peter Siba²  Camila T. França³  Connie S. N. Li Wai Suen³  Louis Schofield⁴  Ivo Mueller⁵ 

[1] Infection and Immunity Division, Walter and Eliza Hall Institute, Parkville, VIC, Australia;Malaria Immuno-Epidemiology Unit, PNG Institute of Medical Research, Madang, Madang Province, Papua New Guinea;Population Health and Immunity Division, Walter and Eliza Hall Institute, Parkville, VIC, Australia;Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia;Population Health and Immunity Division, Walter and Eliza Hall Institute, Parkville, VIC, Australia;Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia;Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, QLD, Australia;Population Health and Immunity Division, Walter and Eliza Hall Institute, Parkville, VIC, Australia;Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia;Malaria Parasites & Hosts Unit, Department of Parasites & Insect Vectors, Institut Pasteur, Paris, France;Barcelona Institute of Global Health (ISGLOBAL), Barcelona, Spain;

关键词: Plasmodium falciparum;    Plasmodium vivax;    Malaria elimination;    IgG antibody;    Biomarker of exposure;    GPI;    Glycosylphosphatidylinositol;    Clinical malaria;    Protection;    Exposure;   

DOI  :  10.1186/s12936-017-2042-2

 received in 2017-08-02, accepted in 2017-09-21,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundFurther reduction in malaria prevalence and its eventual elimination would be greatly facilitated by the development of biomarkers of exposure and/or acquired immunity to malaria, as well as the deployment of effective vaccines against Plasmodium falciparum and Plasmodium vivax. A better understanding of the acquisition of immunity in naturally-exposed populations is essential for the identification of antigens useful as biomarkers, as well as to inform rational vaccine development.MethodsELISA was used to measure total IgG to a synthetic form of glycosylphosphatidylinositol from P. falciparum (PfGPI) in a cohort of 1–3 years old Papua New Guinea children with well-characterized individual differences in exposure to P. falciparum and P. vivax blood-stage infections. The relationship between IgG levels to PfGPI and measures of recent and past exposure to P. falciparum and P. vivax infections was investigated, as well as the association between antibody levels and prospective risk of clinical malaria over 16 months of follow-up.ResultsTotal IgG levels to PfGPI were low in the young children tested. Antibody levels were higher in the presence of P. falciparum or P. vivax infections, but short-lived. High IgG levels were associated with higher risk of P. falciparum malaria (IRR 1.33–1.66, P = 0.008–0.027), suggesting that they are biomarkers of increased exposure to P. falciparum infections. Given the cross-reactive nature of antibodies to PfGPI, high IgG levels were also associated with reduced risk of P. vivax malaria (IRR 0.65–0.67, P = 0.039–0.044), indicating that these antibodies are also markers of acquired immunity to P. vivax.ConclusionsThis study highlights that in young children, IgG to PfGPI might be a useful marker of immune-status to both P. falciparum and P. vivax infections, and potentially useful to help malaria control programs to identify populations at-risk. Further functional studies are necessary to confirm the potential of PfGPI as a target for vaccine development.

【 授权许可】

CC BY   
© The Author(s) 2017