Prognostic factors and multidisciplinary treatment modalities for brain metastases from colorectal cancer: analysis of 93 patients

BMC Cancer

Research Article

Xiao-Dong Gu¹  Zong-You Chen¹  Jian-Bin Xiang¹  Zhen-Yang Li¹  Yi-Ming Zhou¹  Yan-Tao Cai² 

[1] Department of General Surgery, Huashan Hospital, Fudan University, 200040, Shanghai, China;Department of General Surgery, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, 200011, Shanghai, China;

关键词: Colorectal cancer;    Brain metastases;    Surgery;    Radiotherapy;    Prognosis;   

DOI  :  10.1186/s12885-015-1933-2

 received in 2014-06-28, accepted in 2015-11-13,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundThe purpose of this study was to review patient characteristics and evaluate the potential factors affecting prognosis in cases of brain metastasis (BM) from colorectal cancer (CRC).MethodsWe retrospectively reviewed 93 cases of BM from CRC in our hospital. Patient demographics, neurologic symptoms, and location and number of BMs were recorded. Factors analyzed included: age; sex; Karnofsky performance score; number of BMs; presence of extracranial metastases; dimensions; location of tumors; treatment modalities.ResultsThe overall 1- and 2-year survival rates were 27.7 and 9.9 %. On multivariate analysis, the number of BMs, extracranial metastases and the initial treatment modalities were found to be independent prognostic factors for overall survival. Patients treated with surgical resection followed by WBRT or SRS had an improved prognosis relative to those treated with surgery alone (P = 0.02 and P = 0.02, respectively). No significance difference in survival rate was found between patients treated with SRS alone or SRS plus WBRT (P = 0.11).ConclusionsSurgical resection of BMs from CRC in selected patients may help prolong survival. Additional radiotherapy following surgery is valuable in improving prognosis. Extracranial metastasis, multiple BM lesions and initial non operation can be considered as independent factors associated with poor prognosis.

【 授权许可】

CC BY   
© Gu et al. 2015