Stereotactic radiosurgery (SRS) for brain metastases: a systematic review

Radiation Oncology

Laurie E Gaspar³  Anca L Grosu²  Carsten Nieder¹ 

[1] Department of Oncology and Palliative Medicine, Nordland Hospital, 8092 Bodø, Norway;Department of Radiation Oncology, University Hospital Freiburg, 79106 Freiburg, Germany;Department of Radiation Oncology, University of Colorado, 80045 Aurora, CO, USA

关键词: Stereotactic radiosurgery;    Radiotherapy;    Radiation treatment;    Brain metastases;   

Others  :  1152219
DOI  :  10.1186/1748-717X-9-155

 received in 2014-04-25, accepted in 2014-07-09,  发布年份 2014

【 摘 要 】

In many patients with brain metastases, the primary therapeutic aim is symptom palliation and maintenance of neurologic function, but in a subgroup, long-term survival is possible. Local control in the brain, and absent or controlled extracranial sites of disease are prerequisites for favorable survival. Stereotactic radiosurgery (SRS) is a focal, highly precise treatment option with a long track record. Its clinical development and implementation by several pioneering institutions eventually rendered possible cooperative group randomized trials. A systematic review of those studies and other landmark studies was undertaken. Most clinicians are aware of the potential benefits of SRS such as a short treatment time, a high probability of treated-lesion control and, when adhering to typical dose/volume recommendations, a low normal tissue complication probability. However, SRS as sole first-line treatment carries a risk of failure in non-treated brain regions, which has resulted in controversy around when to add whole-brain radiotherapy (WBRT). SRS might also be prescribed as salvage treatment in patients relapsing despite previous SRS and/or WBRT. An optimal balance between intracranial control and side effects requires continued research efforts.

【 授权许可】

   
2014 Nieder et al.; licensee BioMed Central Ltd.

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