Effects of local phenytoin on seroma formation after mastectomy and Axillary lymph node dissection: an experimental study on mice

BMC Surgery

Research Article

Mehmet Eser¹  Fırat Tutal¹  Levent Kaptanoglu¹  Huseyin Uzun¹  Mehmet Gökceimam¹  Selcuk Goktas¹  Metin Kement¹  Melin Ozgun Gecer² 

[1] Department of General Surgery, Kartal Training and Research Hospital, Kartal, Istanbul, Turkey;Department of Pathology, Kartal Training and Research Hospital, Kartal, Istanbul, Turkey;

关键词: Mastectomy;    Lymph node dissection;    Breast cancer;   

DOI  :  10.1186/1471-2482-12-25

 received in 2012-05-28, accepted in 2012-12-04,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundSeroma formation is the most common complication after breast cancer surgery. It is an important complication since it prolongs therapy duration, increases cost, and negatively affects patient psychology. Currently, there is no widely accepted method that prevents seroma formation. We tried to investigate impact of local phenytoin application on seroma formation following an experimental mastectomy model created in rats.MethodsTwo groups including eight rats in each were randomized. Saline injection was applied in the first group, whereas 1% phenytoin was locally used in the second group. Ten days after the surgery, seroma formation and wound-healing processes were evaluated using histopathological and biochemical examinations.ResultsPhenytoin significantly decreased seroma formation. Fibrosis was significantly increased and angiogenesis was significantly reduced in the phenytoin group (P < 0.05). Increased levels of macrophage and lymphocyte infiltration was detected in the control group (P < 0.05). No difference was detected between the groups in terms of necrosis, edema, congestion, and PNL (Polymorphonuclear leucocyte) and fibroblast infiltration.ConclusionsSeroma formation-reducing effect of phenytoin might have occurred over its anti-inflammatory, anti-angiogenetic, and fibrosis augmenting effects.

【 授权许可】

Unknown   
© Eser et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.