Effects of local phenytoin on seroma formation after mastectomy and Axillary lymph node dissection: an experimental study on mice

BMC Surgery

Huseyin Uzun¹  Melin Ozgun Gecer²  Mehmet Gökceimam¹  Levent Kaptanoglu¹  Selcuk Goktas¹  Metin Kement¹  Fırat Tutal¹  Mehmet Eser¹ 

[1] Department of General Surgery, Kartal Training and Research Hospital, Kartal, Istanbul, Turkey;Department of Pathology, Kartal Training and Research Hospital, Kartal, Istanbul, Turkey

关键词: Breast cancer;    Lymph node dissection;    Mastectomy;   

Others  :  1123353
DOI  :  10.1186/1471-2482-12-25

 received in 2012-05-28, accepted in 2012-12-04,  发布年份 2012

【 摘 要 】

Background

Seroma formation is the most common complication after breast cancer surgery. It is an important complication since it prolongs therapy duration, increases cost, and negatively affects patient psychology. Currently, there is no widely accepted method that prevents seroma formation. We tried to investigate impact of local phenytoin application on seroma formation following an experimental mastectomy model created in rats.

Methods

Two groups including eight rats in each were randomized. Saline injection was applied in the first group, whereas 1% phenytoin was locally used in the second group. Ten days after the surgery, seroma formation and wound-healing processes were evaluated using histopathological and biochemical examinations.

Results

Phenytoin significantly decreased seroma formation. Fibrosis was significantly increased and angiogenesis was significantly reduced in the phenytoin group (P < 0.05). Increased levels of macrophage and lymphocyte infiltration was detected in the control group (P < 0.05). No difference was detected between the groups in terms of necrosis, edema, congestion, and PNL (Polymorphonuclear leucocyte) and fibroblast infiltration.

Conclusions

Seroma formation-reducing effect of phenytoin might have occurred over its anti-inflammatory, anti-angiogenetic, and fibrosis augmenting effects.

【 授权许可】

   
2012 Eser et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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