Osseointegration and biocompatibility of different metal implants - a comparative experimental investigation in sheep

BMC Musculoskeletal Disorders

Research Article

Ulrich Stoeckle¹  Alexander Bürki²  Stephen Ferguson³  Karina Klein⁴  Christine Sievert⁴  Katja Nuss⁴  Stefan Stübinger⁵  Peter Kronen⁵  Brigitte von Rechenberg⁵  Daniel Andermatt⁶  Robert Frigg⁶  Michael Plecko⁷ 

[1] Berufsgenossenschaftliche Unfallklinik Tübingen, Schnarrenbergstr.95, D-72076, Tübingen, Germany;Institute for Surgical Technology and Biomechanics, University of Berne, Stauffacherstr.78, CH-3014, Berne, Switzerland;Institute for Surgical Technology and Biomechanics, University of Berne, Stauffacherstr.78, CH-3014, Berne, Switzerland;Institute for Biomechanics, ETH Zurich, Wolfgang-Pauli-Str.10, CH-8093, Zurich, Switzerland;Musculoskeletal Research Unit (MSRU), Equine Hospital, Vetsuisse Faculty, University of Zurich, Winterthurerstr.260, CH-8057, Zurich, Switzerland;Musculoskeletal Research Unit (MSRU), Equine Hospital, Vetsuisse Faculty, University of Zurich, Winterthurerstr.260, CH-8057, Zurich, Switzerland;Competence Center for Applied Biotechnology and Molecular Medicine (CABMM), Equine Hospital, Vetsuisse Faculty, University of Zurich, Winterthurerstr.260, CH-8057, Zurich, Switzerland;Synthes GmbH, Luzernerstr.19, CH-4500, Solothurn, Switzerland;Trauma Hospital, Goestingerstr.24, A - 8021, Graz, Austria;University Hospital Zurich, Devision of Trauma Surgery, Rämistr.100, CH-8091, Zurich, Switzerland;

关键词: Surface Roughness;    Pure Titanium;    Xylenol Orange;    Iliac Wing;    Lower Torque;   

DOI  :  10.1186/1471-2474-13-32

 received in 2011-08-15, accepted in 2012-03-08,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundIn the present study, 4 different metallic implant materials, either partly coated or polished, were tested for their osseointegration and biocompatibility in a pelvic implantation model in sheep.MethodsMaterials to be evaluated were: Cobalt-Chrome (CC), Cobalt-Chrome/Titanium coating (CCTC), Cobalt-Chrome/Zirconium/Titanium coating (CCZTC), Pure Titanium Standard (PTST), Steel, TAN Standard (TANST) and TAN new finish (TANNEW). Surgery was performed on 7 sheep, with 18 implants per sheep, for a total of 63 implants. After 8 weeks, the specimens were harvested and evaluated macroscopically, radiologically, biomechanically (removal torque), histomorphometrically and histologically.ResultsCobalt-Chrome screws showed significantly (p = 0.031) lower removal torque values than pure titanium screws and also a tendency towards lower values compared to the other materials, except for steel. Steel screws showed no significant differences, in comparison to cobalt-chrome and TANST, however also a trend towards lower torque values than the remaining materials. The results of the fluorescence sections agreed with those of the biomechanical test. Histomorphometrically, there were no significant differences of bone area between the groups. The BIC (bone-to-implant-contact), used for the assessment of the osseointegration, was significantly lower for cobalt-chrome, compared to steel (p = 0.001). Steel again showed a lower ratio (p = 0.0001) compared to the other materials.ConclusionThis study demonstrated that cobalt-chrome and steel show less osseointegration than the other metals and metal-alloys. However, osseointegration of cobalt-chrome was improved by zirconium and/or titanium based coatings (CCTC, TANST, TAN, TANNEW) being similar as pure titanium in their osseointegrative behavior.

【 授权许可】

Unknown   
© Plecko et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.