BMC Anesthesiology | |
The efficacy of intravenous paracetamol versus dipyrone for postoperative analgesia after day-case lower abdominal surgery in children with spinal anesthesia: a prospective randomized double-blind placebo-controlled study | |
Research Article | |
Mesut Sener1  Aysu Kocum1  Nesrin Bozdogan Ozyilkan1  Anis Aribogan1  Esra Caliskan2  Semire Serin Ezer3  | |
[1] Department of Anesthesiology and Reanimation, Faculty of Medicine, Baskent University, Ankara, Turkey;Department of Anesthesiology and Reanimation, Faculty of Medicine, Baskent University, Ankara, Turkey;Baskent University Faculty of Medicine, Adana Teaching and Medical Research Center, Baraj Yolu, 1. Durak, No: 37, 01110, Seyhan, Adana, Turkey;Department of Pediatric Surgery, Faculty of Medicine, Baskent University, Ankara, Turkey; | |
关键词: Pediatric spinal anesthesia; Paracetamol; Dipyrone; Postoperative pain; | |
DOI : 10.1186/1471-2253-13-34 | |
received in 2013-05-03, accepted in 2013-10-07, 发布年份 2013 | |
来源: Springer | |
【 摘 要 】
BackgroundA multimodal and preventative approach to providing postoperative analgesia is becoming increasingly popular for children and adults, with the aim of reducing reliance on opioids. We conducted a prospective, randomized double-blind study to compare the analgesic efficacy of intravenous paracetamol and dipyrone in the early postoperative period in school-age children undergoing lower abdominal surgery with spinal anesthesia.MethodsSixty children scheduled for elective lower abdominal surgery under spinal anesthesia were randomized to receive either intravenous paracetamol 15 mg/kg, dipyrone 15 mg/kg or isotonic saline. The primary outcome measure was pain at rest, assessed by means of a visual analog scale 15 min, 30 min, 1 h, 2 h, 4 h and 6 h after surgery. If needed, pethidine 0.25 mg/kg was used as the rescue analgesic. Time to first administration of rescue analgesic, cumulative pethidine requirements, adverse effects and complications were also recorded.ResultsThere were no significant differences in age, sex, weight, height or duration of surgery between the groups. Pain scores were significantly lower in the paracetamol group at 1 h (P = 0.030) and dipyrone group at 2 h (P = 0.010) when compared with placebo. The proportion of patients requiring rescue analgesia was significantly lower in the paracetamol and dipyrone groups than the placebo group (vs. paracetamol P = 0.037; vs. dipyrone P = 0.020). Time to first analgesic requirement appeared shorter in the placebo group but this difference was not statistically significant, nor were there significant differences in pethidine requirements, adverse effects or complications.ConclusionAfter lower abdominal surgery conducted under spinal anesthesia in children, intravenous paracetamol appears to have similar analgesic properties to intravenous dipyrone, suggesting that it can be used as an alternative in the early postoperative period.Trial registrationClinical Trials.gov. Identifier: NCT01858402.
【 授权许可】
CC BY
© Caliskan et al.; licensee BioMed Central Ltd. 2013
【 预 览 】
Files | Size | Format | View |
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RO202311096393094ZK.pdf | 817KB | download |
【 参考文献 】
- [1]
- [2]
- [3]
- [4]
- [5]
- [6]
- [7]
- [8]
- [9]
- [10]
- [11]
- [12]
- [13]
- [14]
- [15]
- [16]
- [17]
- [18]
- [19]
- [20]
- [21]
- [22]
- [23]
- [24]
- [25]
- [26]
- [27]
- [28]
- [29]
- [30]