The efficacy of intravenous paracetamol versus dipyrone for postoperative analgesia after day-case lower abdominal surgery in children with spinal anesthesia: a prospective randomized double-blind placebo-controlled study

BMC Anesthesiology

Esra Caliskan¹  Mesut Sener²  Aysu Kocum²  Nesrin Bozdogan Ozyilkan²  Semire Serin Ezer³  Anis Aribogan² 

[1] Baskent University Faculty of Medicine, Adana Teaching and Medical Research Center, Baraj Yolu, 1. Durak, No: 37, 01110 Seyhan, Adana, Turkey

[2] Department of Anesthesiology and Reanimation, Faculty of Medicine, Baskent University, Ankara, Turkey

[3] Department of Pediatric Surgery, Faculty of Medicine, Baskent University, Ankara, Turkey

关键词: Postoperative pain;    Dipyrone;    Paracetamol;    Pediatric spinal anesthesia;   

Others  :  816737
DOI  :  10.1186/1471-2253-13-34

 received in 2013-05-03, accepted in 2013-10-07,  发布年份 2013

【 摘 要 】

Background

A multimodal and preventative approach to providing postoperative analgesia is becoming increasingly popular for children and adults, with the aim of reducing reliance on opioids. We conducted a prospective, randomized double-blind study to compare the analgesic efficacy of intravenous paracetamol and dipyrone in the early postoperative period in school-age children undergoing lower abdominal surgery with spinal anesthesia.

Methods

Sixty children scheduled for elective lower abdominal surgery under spinal anesthesia were randomized to receive either intravenous paracetamol 15 mg/kg, dipyrone 15 mg/kg or isotonic saline. The primary outcome measure was pain at rest, assessed by means of a visual analog scale 15 min, 30 min, 1 h, 2 h, 4 h and 6 h after surgery. If needed, pethidine 0.25 mg/kg was used as the rescue analgesic. Time to first administration of rescue analgesic, cumulative pethidine requirements, adverse effects and complications were also recorded.

Results

There were no significant differences in age, sex, weight, height or duration of surgery between the groups. Pain scores were significantly lower in the paracetamol group at 1 h (P = 0.030) and dipyrone group at 2 h (P = 0.010) when compared with placebo. The proportion of patients requiring rescue analgesia was significantly lower in the paracetamol and dipyrone groups than the placebo group (vs. paracetamol P = 0.037; vs. dipyrone P = 0.020). Time to first analgesic requirement appeared shorter in the placebo group but this difference was not statistically significant, nor were there significant differences in pethidine requirements, adverse effects or complications.

Conclusion

After lower abdominal surgery conducted under spinal anesthesia in children, intravenous paracetamol appears to have similar analgesic properties to intravenous dipyrone, suggesting that it can be used as an alternative in the early postoperative period.

Trial registration

Clinical Trials.gov. Identifier: NCT01858402.

【 授权许可】

   
2013 Caliskan et al.; licensee BioMed Central Ltd.

【 图 表 】

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