With or without reirradiation in advanced local recurrent nasopharyngeal carcinoma: a case–control study

BMC Cancer

Research Article

Mu-Sheng Zeng¹  Jian-Yong Shao²  Hai-Qiang Mai³  Qiu-Yan Chen³  Lu Zhang³  Hao-Yuan Mo³  Lin-Quan Tang³  Chao-Nan Qian³  Ming-Yuan Chen³  Xiang Guo³  Shan-Shan Guo³  Ling Guo³  Chong Zhao³  Li-Ting Liu³  Ying Sun⁴  Jun Ma⁴  Ming-Huang Hong⁵ 

[1] State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 510060, Guangzhou, China;State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 510060, Guangzhou, China;Department of Molecular Diagnostics, Sun Yat-sen University Cancer Center, 510060, Guangzhou, China;State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 510060, Guangzhou, China;Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, 510060, Guangzhou, China;State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 510060, Guangzhou, China;Department of Radiation Oncology, Sun Yat-sen University Cancer Center, 510060, Guangzhou, People’s Republic of China;State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 510060, Guangzhou, China;Good Clinial Practice Center, Sun Yat-sen University Cancer Center, 510060, Guangzhou, People’s Republic of China;

关键词: Recurrent nasopharyngeal carcinoma;    Reirradiation;    Chemotherapy;   

DOI  :  10.1186/s12885-016-2803-2

 received in 2016-05-03, accepted in 2016-09-22,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe study aimed to evaluate the long-term outcome in patients with advanced local recurrent nasopharyngeal carcinoma (NPC) treated with or without reirradiation.MethodsA total of 44 patients treated without reirradiation (non-RT + chemotherapy) were matched with 44 patients treated with reirradiation (re-RT+/-chemtherapy) by age, sex, Karnosky performance score (KPS), rT stage, rN stage, and time interval between initial radiation and recurrence (TI). Overall survival (OS) rate and time to progression (TTP) rate were assessed using Kaplan–Meier method, log-rank test, and Cox regression analysis.ResultsFrom March 2008 to December 2013, a total of 88 well-balanced rT3–4 N0-1 NPC patients were retrospectively analyzed. After a median follow-up of 27 months (range: 6–85), the 5-year OS rate and TTP rate was 23.4 %, 39.0 % in the non-RT + chemotherapy group and 27.5 %, 49.8 % in the re-RT+/-chemtherapy group, respectively. Multivariate analysis showed that significant toxic effect was the only significant prognosticator correlated with OS (HR: 2.15, 95 % CI = 1.02–4.53, p = 0.044). No statistically significant survival differences were observed between the two treatment groups in either univariate or multivariate analyses.ConclusionCompared with reiradiation, treating advanced local recurrent NPC with chemotherapy alone warrants further validation in the view of its similar survival and more acceptable toxicities.

【 授权许可】

CC BY   
© The Author(s). 2016