The frequency of and risk factors for osteoporosis in Korean patients with rheumatoid arthritis

BMC Musculoskeletal Disorders

Research Article

Jung-Yoon Choe¹  Jisoo Lee²  Hye-Soon Lee³  So-Young Bang³  Dae-Hyun Yoo⁴  Tae-Hwan Kim⁴  Chan-Bum Choi⁴  Yoon-Kyoung Sung⁴  Jae-Bum Jun⁴  Sang-Cheol Bae⁴  Soo-Kyung Cho⁴  Joo-Hyun Lee⁵  Bo Young Yoon⁵  Seung-Jae Hong⁶ 

[1] Department of Rheumatology, Catholic University of Daegu School of Medicine, Daegu, Republic of Korea;Department of Rheumatology, Ewha Womans University Mokdong Hospital, Seoul, Republic of Korea;Department of Rheumatology, Hanyang University Guri Hospital, Guri, Republic of Korea;Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, 133-792, Seoul, Republic of Korea;Department of Rheumatology, Inje University Ilsan Paik Hospital, Goyang, Republic of Korea;Department of Rheumatology, Kyung Hee University Hospital, Seoul, Republic of Korea;

关键词: Osteoporosis;    Rheumatoid arthritis;    Frequency;    Risk factors;   

DOI  :  10.1186/s12891-016-0952-8

 received in 2015-09-03, accepted in 2016-02-17,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe aim of this study was to investigate the prevalence of osteoporosis in rheumatoid arthritis (RA) patients and to analyze the risk factors in these patients using the KORean Observational study Network for Arthritis (KORONA) database.MethodsAmong the RA patients in the KORONA who were recruited between July 2009 and December 2011, postmenopausal women with bone mineral density (BMD) results within one year from the time of KORONA enrollment were included in this study. The baseline characteristics of patients in three groups, defined by BMD results, were compared. The BMD measurement rates and prevalence of osteoporosis in the study patients were calculated in accordance with age and gender subgroups. Multivariable logistic regression analysis was used to explore the association between osteoporosis and demographics and disease-related risk factors.ResultsOf 1322 postmenopausal woman patients with RA in whom BMD was measured within one year of study enrollment, 619 patients (46.8 %) were in the osteoporosis group (T-score ≤ −2.5 SD). RA patients with osteoporosis had a higher frequency of previous fractures than those in other groups, especially fractures of the femur (p = 0.004) and wrist (p = 0.042). Advanced age (≥70 years; OR = 2.28, 95 % CI: 1.40–3.58), lower body mass index (<25; OR = 2.14, 95 % CI:1.52–3.02), longer disease duration (≥10 years; OR = 1.46, 95 % CI: 1.07–2.00), higher cumulative glucocorticoid dose (OR = 1.03, 95 % CI: 1.01–1.05), and higher Health Assessment Questionnaire score (OR = 1.37, 95 % CI:1.11–1.69) were independent risk factors for osteoporosis.ConclusionA large percentage (90.8 %) of RA patients enrolled in the KORONA cohort had osteoporosis and osteopenia. Nevertheless, BMD measurement rates in this population remained low, despite high risk groups of fractures.

【 授权许可】

CC BY   
© Lee et al. 2016