Pretreatment glycemic control status is an independent prognostic factor for cervical cancer patients receiving neoadjuvant chemotherapy for locally advanced disease

BMC Cancer

Research Article

Zhong-qiu Lin¹  Li-juan Wang¹  Qun-xian Rao¹  Jing Li²  Ni-ya Ning³  Rong Chen⁴ 

[1] Department of Gynecologic Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 102 Western Yanjiang Road, 510120, Guangzhou, People’s Republic of China;Department of Gynecologic Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 102 Western Yanjiang Road, 510120, Guangzhou, People’s Republic of China;Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes, Sun Yat-sen University, 510120, Guangzhou, People’s Republic of China;Department of Obstetrics and Gynecology, People’s Hospital of Shaolin District, 462300, Luohe, People’s Republic of China;Health center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 510120, Guangzhou, People’s Republic of China;

关键词: Diabetes mellitus;    Hemoglobin A;    Cervical cancer;    Neoadjuvant chemotherapy;    Prognosis;   

DOI  :  10.1186/s12885-017-3510-3

 received in 2017-02-06, accepted in 2017-07-28,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundTo investigate whether poor glycemic control status has a negative impact on survival outcomes and tumor response to chemotherapy in patients receiving neoadjuvant chemotherapy (NACT) for locally advanced cervical cancer (LACC).MethodsA retrospective cohort study was conducted to examine LACC patients undergoing NACT and radical hysterectomy between 2002 and 2011. Patients were divided into three groups: patients without diabetes mellitus (DM), diabetic patients with good glycemic control, and diabetic patients with poor glycemic control. Hemoglobin A1c (HbA1c) levels were used to indicate glycemic control status. Recurrence-free survival (RFS), cancer-specific survival (CSS) and overall survival (OS) were analyzed using log-rank tests and Cox proportional hazards models.ResultsIn total, 388 patients were included and had a median follow-up time of 39 months (range: 4–67 months). Diabetes mellitus (DM) was diagnosed in 89 (22.9%) patients, only 35 (39.3%) of whom had good glycemic control prior to NACT (HbA1c < 7.0%). In survival analysis, compared with patients with good glycemic control and patients without DM, patients with poor glycemic control (HbA1c ≥ 7.0%) exhibited decreased recurrence-free survival (RFS), cancer-specific survival (CSS) and overall survival (OS). In multivariate analysis, HbA1c ≥ 7.0% was identified as an independent predictor for decreased RFS (hazard ratio [HR] = 3.33, P < 0.0001), CSS (HR = 3.60, P < 0.0001) and OS (HR = 4.35, P < 0.0001). In the subgroup of diabetic patients, HbA1c ≥ 7.0% prior to NACT had an independent negative effect on RFS (HR = 2.18, P = 0.044) and OS (HR = 2.29, P = 0.012). When examined as a continuous variable, the HbA1c level was independently associated with decreased RFS (HR = 1.39, P = 0.002), CSS (HR = 1.28, P = 0.021) and OS (HR = 1.27, P = 0.004). Both good (odds ratio [OR] = 0.06, P < 0.0001) and poor glycemic control (OR = 0.04, P < 0.0001) were independently associated with a decreased likelihood of complete response following NACT.ConclusionsPoor glycemic control is an independent predictor of survival and tumor response to chemotherapy for patients receiving NACT for LACC.

【 授权许可】

CC BY   
© The Author(s). 2017