Evaluating the effect of pupil dilation on spectral-domain optical coherence tomography measurements and their quality score

BMC Ophthalmology

Research Article

Gianluca Manni¹  Luciano Quaranta²  Gloria Roberti³  Francesca Berardo³  Francesco Oddone³  Lucia Tanga³  Manuela Ferrazza³  Marco Centofanti⁴ 

[1] DSCMT, Università di Roma Tor Vergata, Viale Oxford 81, 00133, Rome, Italy;DSMC, Università degli studi di Brescia USVD “Centro per lo studio del Glaucoma”, P.le Spedali Civili, 1 - 25123, Brescia, Italy;IRCCS-Fondazione GB Bietti, Via Livenza 3, 00198, Rome, Italy;IRCCS-Fondazione GB Bietti, Via Livenza 3, 00198, Rome, Italy;DSCMT, Università di Roma Tor Vergata, Viale Oxford 81, 00133, Rome, Italy;

关键词: Optical Coherence Tomography;    Retinal Nerve Fibre Layer;    Optic Nerve Head;    Retinal Nerve Fiber Layer Thickness;    Pupil Dilation;   

DOI  :  10.1186/s12886-015-0168-y

 received in 2014-09-03, accepted in 2015-12-07,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundSpectral-domain optical coherence tomography (SD-OCT) provides fast scan speed and high scan resolution improving its diagnostic accuracy. The purpose of this study was to evaluate if SD-OCT measurements and their quality score are influenced by pupil dilation.MethodsRetinal nerve fiber layer thickness (RNFL), ganglion cell complex (GCC) and optic nerve head (ONH) were measured in one eye of 57 glaucoma patients and 36 healthy subjects using spectral domain optical coherence tomography (SD-OCT) before and after pupil dilation. Comparisons were made between measurements and their quality score pre- and post dilation (Signal Strength Index, SSI). Overall RNFL, average GCC and ONH rim volume were considered in the analysis.ResultsNo statistically significant differences were found between pre- and post-dilation measurements in both groups (glaucoma: RNFL 80 ± 15 μm vs 80 ± 16 μm, p = 0.87; GCC 81.35 ± 13.4 μm vs 81.10 ± 13.14 μm, p = 0.92; ONH 0.05 ± 0.11 mm3 vs 0.04 ± 0.07 mm3, p = 0.74; controls RNFL 99 ± 12 μm vs 98 ± 14 μm, p = 0.70; GCC 92.12 ± 6.7 μm vs 91.54 ± 7.05 μm, p = 0.72; ONH 0.11 ± 0.1 mm3 vs 0.04 ± 0.07 mm3, p = 0.36) nor between pre- and post-dilation quality score (glaucoma SSI RNFL 54.3 ± 10.3 vs 51.7 ± 18.1, p = 0.12; SSI GCC 58 ± 9.5 vs 57 ± 8.09, p = 0.55; SSI ONH 48.5 ± 7.6 vs 46.6 ± 7.2, p = 0.16; controls SSI RNFL 57 ± 10.3 vs 54 ± 9.31, p = 0.2; SSI GCC 60.9 ± 8.1 vs 58.8 ± 7.3, p = 0.3; SSI ONH 51.5 ± 8.9 vs 50.4 ± 8.3, p = 0.59).ConclusionPupil dilation doesn’t affect SD-OCT measurements and their quality score.

【 授权许可】

CC BY   
© Tanga et al. 2015