Multifocal VEP and OCT findings in patients with primary open angle glaucoma: A cross-sectional study

BMC Ophthalmology

Research Article

Marilita M Moschos¹  Chryssanthi Koutsandrea¹  Irini P Chatziralli¹  Gerasimos Georgopoulos¹ 

[1] Department of Ophthalmology, University of Athens, 14578, 6, Ikarias street, EkaliAthens, Greece;

关键词: Glaucoma;    Optical Coherence Tomography;    Retinal Nerve Fiber Layer;    Visual Field Defect;    Retinal Nerve Fiber Layer Thickness;   

DOI  :  10.1186/1471-2415-12-34

 received in 2011-11-27, accepted in 2012-07-23,  发布年份 2012

来源: Springer

【 摘 要 】

BakgroundTo evaluate objectively the anatomical and functional changes of optic nerve in eyes with primary open angle glaucoma (POAG) by the joint use of optical coherence tomography (OCT) and multifocal visual evoked potentials (mfVEP).Methods29 eyes with open angle glaucoma and visual field defects, as well as 20 eyes of 10 age-matched control normal subjects were tested. All participants underwent a complete ophthalmological examination. Moreover, Humphrey visual field test, OCT examination and recording of mfVEP were performed. Amplitude and implicit time of mfVEP, as well as RNFL thickness were measured. Differences in density components of mfVEP and in RNFL thickness among POAG eyes and control eyes were examined using Student’s t-test.ResultsIn glaucomatous eyes the mean Retinal Response Density (RRD) was lower than normal in ring 1, 2 and 3 of mfVEP (p < 0.0001). Specifically the mean amplitude of mfVEP in POAG eyes was estimated at 34.2 ± 17.6 nV/deg2, 6.9 ± 4.8 nV/deg2 and 2.6 ± 1.6 nV/deg2 in rings 1, 2 and 3 respectively. In contrast the mean implicit time was similar to control eyes. In addition, the mean RNFL thickness in POAG eyes was estimated at 76.8 ± 26.6 μm in the superior area, 52.1 ± 16.3 μm in the temporal area, 75.9 ± 32.5 μm in the inferior area and 58.6 ± 19.4 μm in the nasal area. There was a statistically significant difference in RNFL thickness in all peripapillary areas (p < 0.0001) between POAG eyes and controls, with superior and inferior area to present the highest decrease.ConclusionsOur study shows that, although Standard Automatic Perimetry is the gold standard to evaluate glaucomatous neuropathy, the joint use of mfVEP and OCT could be useful in better monitoring glaucoma progression.

【 授权许可】

CC BY   
© Moschos et al.; licensee BioMed Central Ltd. 2012