Catheter for endoscopic magnetomotive optical coherence tomography

Optical Coherence Tomography;Catheter;Magnetomotive optical coherence tomography (OCT)

Li, Di ; Boppart ; Stephen A.

关键词: Optical Coherence Tomography;    Catheter;    Magnetomotive optical coherence tomography (OCT);   

Others  :  https://www.ideals.illinois.edu/bitstream/handle/2142/18621/Li_Di.pdf?sequence=1&isAllowed=y

美国|英语

来源: The Illinois Digital Environment for Access to Learning and Scholarship

【 摘 要 】

In this thesis, a catheter design is proposed for endoscopic magnetomotive optical coherence tomography (MM-OCT). Magnetomotive optical coherence tomography is a novel technique which uses targeted magnetic contrast agents for contrast enhancement of OCT imaging. In MM-OCT, microspheres and magnetic nanoparticles (MNPs) are introduced into tissue and an electromagnet is used to generate a small modulated magnetic field within the tissue during OCT imaging. The magnetic field will introduce mechanical displacement of the MNPs, which can be detected, and the MM-OCT signal can be measured. The current bench-top set-up does not allow for in vivo MM-OCT imaging because the magnetic field is provide by a solenoid with an outer diameter of ~18 mm and an axial thickness of ~9 mm. A magnetomotive catheter design was developed by wrapping small coil around the distal end of a standard OCT catheter to combine the novel MM-OCT technology and catheter-based OCT. The coil has a small size while providing a local magnetic field for MM-OCT imaging. This magnetomotive catheter will enable investigations of in vivo magnetomotive contrast enhancement from the magnetic agents used in MM-OCT imaging.