Evaluation of therapeutic potentials of plant extracts against poultry bacteria threatening public health

BMC Complementary and Alternative Medicine

Research Article

John Olayiwola¹  Moses Abiala²  Oluwatoyin Babatunde³  Olapeju Aiyelaagbe⁴  Sunday Akinyemi⁵ 

[1] Department of Biological Sciences, Ajayi Crowther University, Oyo, Nigeria;Department of Biological Sciences, Ajayi Crowther University, Oyo, Nigeria;Department of Biological Sciences, Mountain Top University, Prayer City, Nigeria;Department of Chemical Sciences, Ajayi Crowther University, Oyo, Nigeria;Department of Chemistry, University of Ibadan, Ibadan, Nigeria;Fruits and Biotechnology Unit, National Horticultural Research Institute, Ibadan, Nigeria;

关键词: Poultry;    Antimicrobial;    Multidrug resistant bacteria;    Extracts;    Public health;   

DOI  :  10.1186/s12906-016-1399-z

 received in 2016-05-06, accepted in 2016-10-11,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundPlant extracts were evaluated on poultry bacteria known to be threatening public health. This is to develop better bio-therapeutic agents from plant origin.MethodsBacteria were isolated from water, feed, crop, gizzard and faeces of layer chicken. Isolates of interest (Escherichia coli, Salmonella enteritidis, Pseudomonas aeruginosa and Klebsiella oxytoca) were subjected to antibiotic susceptibility test. Resistant strains were further evaluated against different plant extracts in comparison to Meropenem (control) using agar diffusion method.ResultsE. coli had the highest occurrence (53 %), followed by P. aeruginosa (25 %) and then S. enteritidis (13 %) while the least was K. oxytoca (9 %). Virtually all the isolates exhibited multi-antibiotic resistance (MAR) with gross resistance to Amoxicillin, Erythromycin and Cefuroxine. P. aeruginosa (75 %), S. enteritidis (75 %) and E. coli (63 %), had the highest MAR. Out of the 11 (100 %) plant extracts evaluated, 7 (64 %) were outstanding and showed varied levels of antibacterial activity. Specifically, methanol extract of Mangifera indica Julie cultivar leaf (MJLM) had the highest antibacterial activity, followed by Euadenia trifoliata stem bark (TB03) and Euadenia eminens leaf (TB05). P. aeruginosa was highly susceptible (81.81 %) to the extracts, followed by S. enteritidis (63.64 %) and then E. coli (27.27 %).ConclusionsMJLM and other extracts have proven to be promising extracts in which to search for bioactive components that can be developed into therapeutic drugs. This may help in the management of antibiotic resistant bacterial isolates from poultry chicken threatening public health.

【 授权许可】

CC BY   
© The Author(s). 2016