Maternal 27-hydroxycholesterol concentrations during the course of pregnancy and in pregnancy pathologies

BMC Pregnancy and Childbirth

Research Article

Markus Mohaupt¹  Geneviève Escher¹  Laila Najjari²  Brigitte Sophia Winkler²  Nicola Kleine-Eggebrecht²  Nicolai Maass³  Ulrich Pecks³ 

[1] Department of Nephrology, Hypertension and Clinical Pharmacology, Inselspital, Department of Clinical Research, University of Bern, Freiburgstrasse, 3010, Berne, Switzerland;Department of Obstetrics and Gynecology, University Hospital of RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany;Department of Obstetrics and Gynecology, University Hospital of RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany;Department of Obstetrics and Gynecology, University Hospital of Schleswig-Holstein, Michaelisstraße 16, 24105, Kiel, Germany;

关键词: 27-hydroxycholesterol;    27-OHC/TC ratio;    Preeclampsia;    HELLP-syndrome;    Intrauterine growth restriction;    Intrahepatic cholestasis in pregnancy;    Lipid metabolism;   

DOI  :  10.1186/s12884-017-1287-7

 received in 2015-12-08, accepted in 2017-03-22,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe oxysterol 27-hydroxycholesterol (27-OHC) plays an important role in the regulation of cholesterol homeostasis. Pregnancy pathologies like preeclampsia (PE), HELLP-syndrome (HELLP), intrauterine growth restriction (IUGR) and intrahepatic cholestasis in pregnancy (ICP) are linked to disturbances in lipid metabolism. In the present study, we hypothesized a specific gestational regulation of 27-OHC and compromised 27-OHC levels due to placental and hepatic diseases in pregnancy resulting in a dysregulation of lipid metabolism.MethodsThe 27-OHC was measured by gas-chromatography-mass spectrometry (GC-MS) and related to cholesterol concentrations. In the longitudinal cohort, a complete set of samples of healthy patients (n = 33) obtained at three different time points throughout gestation and once post-partum was analyzed. In the cross sectional cohort, patients with pregnancy pathologies (IUGR n = 14, PE n = 14, HELLP n = 7, ICP n = 7) were matched to a control group (CTRL) of equal gestational ages.ResultsThe 27-OHC levels already increased in the first trimester despite lower TC concentrations (p < 0.05). During the course of pregnancy, a subtle rise in 27-OHC concentrations results in an overall decrease of 27-OHC/TC ratio in between the first (p < 0.05) and second trimester. The ratio remains stable thereafter including the post-partum period. No significant differences have been observed in pregnancy pathologies as compared to the CTRL group.ConclusionIn conclusion, 27-OHC may have a compensatory role in cholesterol metabolism early in pregnancy. The conserved 27-OHC/TC ratio in pregnancy pathologies suggest that neither the placenta nor the liver is majorly involved in the regulation of 27-OHC metabolism.

【 授权许可】

CC BY   
© The Author(s). 2017