Blood pressure and proteinuria control remains a challenge in patients with type 2 diabetes mellitus and chronic kidney disease: experience from the prospective observational ALICE-PROTECT study

BMC Nephrology

Research Article

Bertrand Dussol¹  Stéphane Quéré²  Béatrice Fiquet²  Christian Combe³  Jean-Pierre Fauvel⁴  Jean-Michel Halimi⁵  Dominique Joly⁶  Gabriel Choukroun⁷ 

[1] Aix-Marseille Université, Faculté de Médecine, Centre de Néphrologie et de Transplantation Rénale, Hôpital de la Conception, Marseille, France;Clinical Affairs, Biostatistics, Clinical Research and Development, Novartis Pharma SAS, Rueil-Malmaison, France;Université Bordeaux Segalen, Service de Néphrologie Transplantation Dialyse, CHU de Bordeaux and INSERM U1026, Bordeaux, France;Université Claude Bernard Lyon, Department of Nephrology-Hypertension, Génomique Fonctionnelle de l’Hypertension artérielle, EA 4173, Hôpital Nord-Ouest, Villefranche sur Saône, Hospices Civils de Lyon, Lyon, France;Université François-Rabelais, Faculté de Médecine, Service de Néphrologie-Immunologie Clinique, Hôpital Bretonneau, CHU Tours and EA4245, Tours, France;Université Paris-Descartes, Faculté de Médecine, AP-HP; Service de Néphrologie, Hôpital Necker-Enfants Malades, Paris, France;Université de Picardie Jules Verne, Département de Néphrologie Dialyse Transplantation, CHU Amiens et INSERN UMR 1088, Amiens, France;

关键词: Type 2 diabetes mellitus;    Nephropathy;    Blood pressure;    Proteinuria;    Cardiovascular events;    End stage renal disease;    ALICE Protect study;   

DOI  :  10.1186/s12882-016-0336-1

 received in 2015-06-23, accepted in 2016-08-23,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundType 2 diabetes (T2DM) is the leading cause of chronic kidney disease (CKD) in western countries. The combination of both increases the risk of end stage renal disease (ESRD), cardiovascular events and all-cause mortality. Early control of blood pressure (BP) and proteinuria (Pu) is crucial to slow down the progression of the CKD and prevent cardiovascular events and mortality. The primary objective of the study was to assess BP and Pu control after a 2-year follow-up in T2DM patients with CKD.MethodsProspective, multicenter, observational study. Overall, 153 French nephrologists included 986 T2DM patients with Pu (≥0.5 g/day) and an eGFR >15 ml/min/1.73 m2. Data from 729 patients were available after a 2-year follow-up. BP and Pu control were respectively defined as less than 140/90 mmHg and 0.5 g/day. We also looked at renal and cardiovascular events.ResultsAt baseline, 74 % of the patients were male, mean age was 70 years. The mean T2DM duration was 17 years with a mean HbA1c of 7.4 %. All were treated for hypertension and 33 % had a controlled BP; 81 % had dyslipidemia and LDLc was <1 g/L for 54 %; 44 % had retinopathy, 40 % macrovascular complications and 12 % heart failure. Mean Pu was 2 g/day and eGFR 40 ± 20 mL/min/1.73 m2, with 13, 18, 32 and 37 % of the patients in respectively stage 2, 3a, 3b and 4 CKD.After two years, 21 % reached the Pu target and 39 % the BP target. The mean eGFR of 40 ± 20.3 ml/min/1.73 m2 at baseline dropped to 33.9 ± 22.6 ml/min/1.73 m2 by year two (p < 0.001). This corresponded to a mean annual eGFR reduction of 3.2 ml/min/1.73 m2. 118 patients presented a renal event (16.2 %): doubling of serum creatinine for 86 patients (11.8 %) and start of dialysis for 72 (9.9 %); 176 patients (24.1 %) developed at least one cardiovascular complication (mainly coronary events and acute heart failure) during the follow-up period, and among these, 50 had also developed renal complications. Sixty patients died, i.e., 8.2 %, 26 patients from cardiovascular causes.ConclusionOur study highlights that achieving BP and Pu targets remains a major challenge in patients with T2DM and nephropathy. Renal failure emerges as a more frequent event than death.

【 授权许可】

CC BY   
© The Author(s). 2016