Does infection with human immunodeficiency virus have any impact on the cardiovascular outcomes following percutaneous coronary intervention?: a systematic review and meta-analysis

BMC Cardiovascular Disorders

Research Article

Manish Pursun¹  Pravesh Kumar Bundhun²  Wei-Qiang Huang³ 

[1] Guangxi Medical University, 530027, Nanning, Guangxi, People’s Republic of China;Institute of Cardiovascular Diseases, the First Affiliated Hospital of Guangxi Medical University, 530027, Nanning, Guangxi, People’s Republic of China;Institute of Cardiovascular Diseases, the First Affiliated Hospital of Guangxi Medical University, 530027, Nanning, Guangxi, People’s Republic of China;Institute of Cardiovascular Diseases, the First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, Guangxi, People’s Republic of China;

关键词: Human immunodeficiency virus;    Percutaneous coronary intervention;    Cardiovascular outcomes;    Acquired immune deficiency syndrome;    Coronary artery disease;    Highly active antiretroviral therapy;   

DOI  :  10.1186/s12872-017-0624-0

 received in 2016-10-11, accepted in 2017-07-12,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundA direct link between human immunodeficiency virus (HIV)-infected patients and the risk of cardiovascular diseases (CVD) has been shown in recent scientific research. However, this issue is controversial since other previous reports showed no apparent impact of HIV or its anti-retroviral drugs on the cardiovascular system. We aimed to systematically compare the postinterventional adverse cardiovascular outcomes which were observed in patients with and without HIV infection during a mean follow up period ranging from 1 year to 3 years.MethodsCommon electronic databases were searched for studies which compared postinterventional adverse cardiovascular outcomes [mortality, myocardial infarction (MI), cardiac death, target vessel revascularization (TVR), target lesion revascularization (TLR), stroke and major adverse cardiac events (MACEs)] in patients with and without HIV infection. Statistical analysis was carried out by the RevMan 5.3 software whereby Odds Ratios (OR) and 95% Confidence Intervals (CIs) were generated.ResultsTwo thousand two hundred and sixty-eight (2268) patients (821 patients were HIV positive and 1147 patients were HIV negative) were analyzed. The current results showed that mortality was not significantly increased among patients who were HIV positive with OR: 1.13, 95% CI: 0.65–1.96; P = 0.66. Cardiac death was also similarly reported with OR: 1.16, 95% CI: 0.50–2.68; P = 0.74. However, even if recurrent MI, TVR, TLR, MACEs and stroke were higher in patients who were HIV positive, with OR: 1.32, 95% CI: 0.88–2.12; P = 0.18, OR: 1.36, 95% CI: 0.88–2.12; P = 0.17, OR: 1.22, 95% CI: 0.72–2.06; P = 0.46, OR: 1.29, 95% CI: 0.89–1.85; P = 0.17 and OR: 1.47, 95% CI: 0.44–4.89; P = 0.53 respectively, these results were not statistically significant.ConclusionPatients who were infected with HIV had similar mortality post coronary intervention compared to patients who were not infected by the virus, during a mean follow-up period of 1–3 years. In addition, no significant increase in MI, TVR, TLR, MACEs and stroke were observed during this follow up period. Therefore, it might be concluded that no apparent impact of HIV on the cardiovascular outcomes was observed post coronary intervention.

【 授权许可】

CC BY   
© The Author(s). 2017