The effects of Cordyceps sinensis phytoestrogen on estrogen deficiency-induced osteoporosis in Ovariectomized rats

BMC Complementary and Alternative Medicine

Research Article

Zhen-lin Wang¹  Guang-yue Zhao²  Da-wei Zhang²  Wei Qi³ 

[1] Department of Orthopedic Surgery, the NO.113 hospital of PLA, 315000, Ningbo, People’s Republic of China;Department of Orthopedics, Xi Jing Hospital, the Fourth Military Medical University, 710032, Xi’an, People’s Republic of China;Department of Orthopedics, Xi Jing Hospital, the Fourth Military Medical University, 710032, Xi’an, People’s Republic of China;The Surgery Department of 520th Hospital of PLA, 621000, Mian Yang, People’s Republic of China;

关键词: Cordyceps sinensis;    Isoflavones;    Osteoporosis;    Phytoestrogen;    Estrogens;   

DOI  :  10.1186/1472-6882-14-484

 received in 2014-02-19, accepted in 2014-12-10,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundIsoflavones are naturally occurring plant chemicals belonging to the “phytoestrogen” class. The aim of the present study was to examine the effects of isoflavones obtained from Cordyceps sinensis (CSIF) on development of estrogen deficiency-induced osteoporosis in ovariectomized rats.MethodsAfter the rats were treated orally with CSIF, serum alkaline phosphatase (ALP), tartarate resistant acid phosphatase (TRAP), serum osteocalcin (OC), homocysteine (HCY), C-terminal crosslinked telopeptides of collagen type I (CTX), estradiol and interferonγ (IFN-γ) level were examined. At the same time, the urine calcium, plasma calcium, plasma phosphorus and the mass of uterus, thymus and body were also examined.ResultsThe beneficial effects of CSIF on improvement of osteoporosis in rats were attributable mainly to decrease ALP activity, TRAP activity, CTX level and IFN-γ level. At the same time, CSIF also increase the OC and estradiol level in ovariectomized osteopenic rats. The histological examination clearly showed that dietary CSIF can prevent bone loss caused by estrogen deficiency.ConclusionThe significant estrogenic activity of CSIF demonstrated that CSIF has significant estrogenic effects in OVX rats.

【 授权许可】

Unknown   
© Zhang et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.