The effects of Cordyceps sinensis phytoestrogen on estrogen deficiency-induced osteoporosis in Ovariectomized rats

BMC Complementary and Alternative Medicine

Guang-yue Zhao¹  Wei Qi²  Zhen-lin Wang³  Da-wei Zhang¹ 

[1] Department of Orthopedics, Xi Jing Hospital, the Fourth Military Medical University, Xi’an 710032, People’s Republic of China;The Surgery Department of 520th Hospital of PLA, Mian Yang 621000, People’s Republic of China;Department of Orthopedic Surgery, the NO.113 hospital of PLA, Ningbo 315000, People’s Republic of China

关键词: Estrogens;    Phytoestrogen;    Osteoporosis;    Isoflavones;    Cordyceps sinensis;   

Others  :  1084955
DOI  :  10.1186/1472-6882-14-484

 received in 2014-02-19, accepted in 2014-12-10,  发布年份 2014

【 摘 要 】

Background

Isoflavones are naturally occurring plant chemicals belonging to the “phytoestrogen” class. The aim of the present study was to examine the effects of isoflavones obtained from Cordyceps sinensis (CSIF) on development of estrogen deficiency-induced osteoporosis in ovariectomized rats.

Methods

After the rats were treated orally with CSIF, serum alkaline phosphatase (ALP), tartarate resistant acid phosphatase (TRAP), serum osteocalcin (OC), homocysteine (HCY), C-terminal crosslinked telopeptides of collagen type I (CTX), estradiol and interferonγ (IFN-γ) level were examined. At the same time, the urine calcium, plasma calcium, plasma phosphorus and the mass of uterus, thymus and body were also examined.

Results

The beneficial effects of CSIF on improvement of osteoporosis in rats were attributable mainly to decrease ALP activity, TRAP activity, CTX level and IFN-γ level. At the same time, CSIF also increase the OC and estradiol level in ovariectomized osteopenic rats. The histological examination clearly showed that dietary CSIF can prevent bone loss caused by estrogen deficiency.

Conclusion

The significant estrogenic activity of CSIF demonstrated that CSIF has significant estrogenic effects in OVX rats.

【 授权许可】

   
2014 Zhang et al.; licensee BioMed Central Ltd.

【 图 表 】

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