Antimicrobial activity of selected South African medicinal plants

BMC Complementary and Alternative Medicine

Research Article

Victor Kuete¹  Anna K Jäger²  Trine R H Nielsen³  Jacobus J Marion Meyer⁴  Namrita Lall⁴ 

[1] Department of Biochemistry, Faculty of science, University of Dschang, P.O. Box 67, Dschang, Cameroon;Department of Plant Science, Faculty of Agricultural and Biological Science, 0002, Pretoria, South Africa;Department of Medicinal Chemistry Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark;Department of Medicinal Chemistry Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark;Department of Plant Science, Faculty of Agricultural and Biological Science, 0002, Pretoria, South Africa;Department of Plant Science, Faculty of Agricultural and Biological Science, 0002, Pretoria, South Africa;

关键词: Tuberculosis;    Minimal Inhibition Concentration;    Crude Extract;    Growth Index;    Mycobacterium Smegmatis;   

DOI  :  10.1186/1472-6882-12-74

 received in 2012-01-19, accepted in 2012-06-14,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundNearly 3,000 plant species are used as medicines in South Africa, with approximately 350 species forming the most commonly traded and used medicinal plants. In the present study, twelve South African medicinal plants were selected and tested for their antimicrobial activities against eight microbial species belonging to fungi, Mycobacteria, Gram-positive and Gram-negative bacteria.MethodsThe radiometric respiratory technique using the BACTEC 460 system was used for susceptibility testing against Mycobacterium tuberculosis, and the liquid micro-broth dilution was used for other antimicrobial assays.ResultsThe results of the minimal inhibitory concentration (MIC) determinations indicated that the methanol extracts from Acacia karoo, Erythrophleum lasianthum and Salvia africana were able to prevent the growth of all the tested microorganisms. All other samples showed selective activities. MIC values below 100 μg/ml were recorded with A. karoo, C. dentate, E. lasianthum, P. obligun and S. africana on at least one of the nine tested microorganisms. The best activity (MIC value of 39.06 μg/ml) was noted with S. africana against E. coli, S. aureus and M. audouinii, and Knowltonia vesitoria against M. tuberculosis.ConclusionThe overall results of the present work provide baseline information for the possible use of the studied South African plant extracts in the treatment of microbial infections.

【 授权许可】

Unknown   
© Nielsen et al.; licensee Biomed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.