Risk factors and outcomes of postoperative pancreatic fistula after pancreatico-duodenectomy: an audit of 532 consecutive cases

BMC Surgery

Research Article

Shun-Jun Fu¹  Shun-Li Shen²  Yun-Peng Hua²  Wen-Jie Hu²  Ming Kuang²  Li-Jian Liang²  Shao-Qiang Li²  Bao-Gang Peng² 

[1] Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of TCM), 510120, Guangzhou, P.R. China;Department of Hepatobiliary Surgery, the First Affiliated Hospital, Sun Yat-sen University, 510080, Guangzhou, P.R. China;Department of Hepatobiliary Surgery, the First Affiliated Hospital, Sun Yat-sen University, 510080, Guangzhou, P.R. China;

关键词: Pancreatic fistula;    Pancreaticoduodenectomy;    Risk factor;    Outcome;   

DOI  :  10.1186/s12893-015-0011-7

 received in 2014-10-18, accepted in 2015-02-13,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundPancreatic fistula (PF) remains the most challenging complication after pancreaticoduodenectomy (PD). The purpose of this study was to identify the risk factors of PF and delineate its impact on patient outcomes.MethodsWe retrospectively reviewed clinical data of 532 patients who underwent PD and divided them into PF group and no PF group. Risk factors and outcomes of PF following PD were examined.ResultsPF was found in 65 (12.2%) cases, of whom 11 were classified into ISGPF grade A, 42 grade B, and 12 grade C. Clinically serious postoperative complications in the PF versus no PF group were mortality, abdominal bleeding, bile leak, intra-abdominal abscess and pneumonia. Univariate and multivariate analysis showed that blood loss ≥ 500 ml, pancreatic duct diameter ≤ 3 mm and pancreaticojejunostomy type were independent risk factors of PF after PD.ConclusionsBlood loss ≥ 500 ml, pancreatic duct diameter ≤ 3 mm and pancreatico-jejunostomy type were independent risk factors of PF after PD. PF was related with higher mortality rate, longer hospital stay, and other complications.

【 授权许可】

Unknown   
© Fu et al.; licensee BioMed Central. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.