Risk factors and outcomes of postoperative pancreatic fistula after pancreatico-duodenectomy: an audit of 532 consecutive cases

BMC Surgery

Bao-Gang Peng¹  Li-Jian Liang¹  Ming Kuang¹  Yun-Peng Hua¹  Wen-Jie Hu¹  Shao-Qiang Li¹  Shun-Li Shen¹  Shun-Jun Fu² 

[1] Department of Hepatobiliary Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, PR China;Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of TCM), Guangzhou 510120, PR China

关键词: Outcome;    Risk factor;    Pancreaticoduodenectomy;    Pancreatic fistula;   

Others  :  1145780
DOI  :  10.1186/s12893-015-0011-7

 received in 2014-10-18, accepted in 2015-02-13,  发布年份 2015

【 摘 要 】

Background

Pancreatic fistula (PF) remains the most challenging complication after pancreaticoduodenectomy (PD). The purpose of this study was to identify the risk factors of PF and delineate its impact on patient outcomes.

Methods

We retrospectively reviewed clinical data of 532 patients who underwent PD and divided them into PF group and no PF group. Risk factors and outcomes of PF following PD were examined.

Results

PF was found in 65 (12.2%) cases, of whom 11 were classified into ISGPF grade A, 42 grade B, and 12 grade C. Clinically serious postoperative complications in the PF versus no PF group were mortality, abdominal bleeding, bile leak, intra-abdominal abscess and pneumonia. Univariate and multivariate analysis showed that blood loss ≥ 500 ml, pancreatic duct diameter ≤ 3 mm and pancreaticojejunostomy type were independent risk factors of PF after PD.

Conclusions

Blood loss ≥ 500 ml, pancreatic duct diameter ≤ 3 mm and pancreatico-jejunostomy type were independent risk factors of PF after PD. PF was related with higher mortality rate, longer hospital stay, and other complications.

【 授权许可】

   
2015 Fu et al.; licensee BioMed Central.

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