Migraine is associated with an increased risk for benign paroxysmal positional vertigo: a nationwide population-based study

The Journal of Headache and Pain

Research Article

Tzeng-Ji Chen¹  Shuu-Jiun Wang²  Chia-Huei Chu³  Liang-Yu Lin⁴  Chia-Jen Liu⁵ 

[1] Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan;Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan;Department of Neurology, National Yang-Ming University School of Medicine, Taipei, Taiwan;Institute of Brain Science, National Yang-Ming University School of Medicine, Taipei, Taiwan;Brain Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan;Department of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan;Department of Otorhinolaryngology, National Yang-Ming University School of Medicine, Taipei, Taiwan;Division of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan;Department of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan;Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan;Institute of Public Health, National Yang-Ming University School of Medicine, Taipei, Taiwan;

关键词: Migraine;    Benign paroxysmal positional vertigo;    Risk factors;    Incidence rate;   

DOI  :  10.1186/s10194-015-0547-z

 received in 2015-04-22, accepted in 2015-06-24,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundThere is evidence suggesting that migraine may be associated with vertigo. The aim of this study was to assess the risk of benign paroxysmal positional vertigo (BPPV), the most common form of vertigo, in patients with migraine using a population-based dataset.MethodsThe National Health Insurance Research Database in Taiwan was searched for migraine patients and was also used to select an age- and sex-matched cohort of subjects without migraine. The analyses included 8266 migraine patients and 8266 controls. The incidence rates of BPPV in the two cohorts were compared. Cox proportional hazard models were used to identify risk factors for BPPV in migraine patients.ResultsIn the migraine cohort, 1.11 % of the patients developed BPPV compared to 0.5 % of the controls. The incidence rate ratio was 2.03 (95 % CI 1.41–2.97; p <0.001). Cox proportional hazards analysis showed that age ≥40 years (HR 2.20; 95 % CI 1.40–3.45; p = 0.001), coronary artery disease (HR 4.62; 95 % CI 1.12–19.01; p = 0.034), and the number of outpatient department visits to neurologists because of migraine (HR 2.93; 95 % CI 2.50–3.44; p >0.001) were associated with an increased risk for BPPV.ConclusionThe results showed that patients with migraine had a 2.03-fold increased risk of developing BPPV compared with age- and sex-matched controls. Although BPPV may not be a common condition in migraine patients, migraine sufferers with vestibular symptoms should alert physicians to the possibility of BPPV, particularly if patients are aged ≥40 years, have a history of coronary artery disease, or have frequent visits to neurologists clinics because of migraine.

【 授权许可】

Unknown   
© Chu et al. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.