Changes in visual-evoked potential habituation induced by hyperventilation in migraine

The Journal of Headache and Pain

Original

Alessia Alibardi¹  Antonio Curr๠ Simona Liliana Sava²  Francesco Pierelli³  Gianluca Coppola⁴  Vincenzo Parisi⁵  Jean Schoenen⁶ 

[1] Department of Medical and Surgical Sciences and Biotechnologies, Ospedale A. Fiorini, “Sapienza” University of Rome - Polo Pontino, Latina, Italy;Department of Medical and Surgical Sciences and Biotechnologies, “Sapienza” University of Rome - Polo Pontino, ICOT, Latina, Italy;Department of Medical and Surgical Sciences and Biotechnologies, “Sapienza” University of Rome - Polo Pontino, ICOT, Latina, Italy;IRCCS-Neuromed, Pozzilli (IS), Italy;Department of Neurophysiology of Vision and Neurophthalmology, G.B. Bietti Eye Foundation-IRCCS, Via Livenza 3, 00198, Rome, Italy;Department of Neurophysiology of Vision and Neurophthalmology, G.B. Bietti Eye Foundation-IRCCS, Via Livenza 3, 00198, Rome, Italy;University of Rome “Campus Biomedico”, Rome, Italy;Headache Research Unit, University Department of Neurology and GIGA-Neurosciences, Liège University, Liège, Belgium;

关键词: Migraine;    Hyperventilation;    Visual-evoked potentials;    Habituation;    Brainstem;    Thalamo-cortical activity;   

DOI  :  10.1007/s10194-010-0239-7

 received in 2010-04-26, accepted in 2010-06-24,  发布年份 2010

来源: Springer

【 摘 要 】

Hyperventilation is often associated with stress, an established trigger factor for migraine. Between attacks, migraine is associated with a deficit in habituation to visual-evoked potentials (VEP) that worsens just before the attack. Hyperventilation slows electroencephalographic (EEG) activity and decreases the functional response in the occipital cortex during visual stimulation. The neural mechanisms underlying deficient-evoked potential habituation in migraineurs remain unclear. To find out whether hyperventilation alters VEP habituation, we recorded VEPs before and after experimentally induced hyperventilation lasting 3 min in 18 healthy subjects and 18 migraine patients between attacks. We measured VEP P100 amplitudes in six sequential blocks of 100 sweeps and habituation as the change in amplitude over the six blocks. In healthy subjects, hyperventilation decreased VEP amplitude in block 1 and abolished the normal VEP habituation. In migraine patients, hyperventilation further decreased the already low block 1 amplitude and worsened the interictal habituation deficit. Hyperventilation worsens the habituation deficit in migraineurs possibly by increasing dysrhythmia in the brainstem-thalamo-cortical network.

【 授权许可】

Unknown   
© Springer-Verlag 2010