Lateral inhibition in visual cortex of migraine patients between attacks

The Journal of Headache and Pain

Research Article

Gianluca Coppola¹  Vincenzo Parisi¹  Mariano Serrao²  Cherubino Di Lorenzo³  Jean Schoenen⁴  Delphine Magis⁴  Francesco Pierelli⁵ 

[1] Departmen of Neurophysiology of Vision and Neuroophtalmology, G.B. Bietti Foundation IRCCS, Via Livenza, 3-00198, Rome, Italy;Department of Medico-Surgical Sciences and Biotechnologies, “Sapienza” University of Rome Polo Pontino, Latina, Italy;Don Carlo Gnocchi Onlus Foundation, Lombardy, Italy;Headache Research Unit. University Dept. of Neurology & GIGA-Neurosciences, Liège University, Liège, Belgium;IRCCS-Neuromed, Pozzilli, (IS), Italy;

关键词: Habituation;    Migraine;    Short-range lateral inhibition;    Thalamo-cortical dysrhythmia;    Visual evoked potentials;   

DOI  :  10.1186/1129-2377-14-20

 received in 2012-12-22, accepted in 2013-02-25,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundThe interictal deficit of habituation to repetitive visual stimuli in migraine patients could be due to deficient intracortical inhibition and/or to low cortical pre-activation levels. Which of these abnormalities contributes more to the habituation deficit cannot be determined with the common methods used to record transient visual responses.We investigated lateral inhibition in the visual cortex during the migraine cycle and in healthy subjects by using differential temporal modulations of radial windmill-dartboard (WD) or partial-windmill (PW) visual patterns.MethodsTransient (TR-VEP) and steady-state visual-evoked potentials (SS-VEP) were recorded in 65 migraine patients (21 without and 22 with aura between attacks; 22 patients during an attack) and in 21 healthy volunteers (HV). Three stimulations were used in each subject: classic checkerboard pattern (contrast-reversion 3.1Hz), WD and PW (contrast-reversion ~4Hz). For each randomly presented stimulation protocol, 600 sweeps were acquired and off-line partitioned in 6 blocks of 100. Fourier analysis allowed data to extract in SS-VEP the fundamental (1H) and the second harmonic (2H) components that reflect respectively short-(WD) and long- range lateral inhibition (attenuation of 2H in WD compared to PW).ResultsCompared to HV, migraineurs recorded interictally had significantly less habituation of the N1-P1 TR-VEP component over subsequent blocks and they tended to have a smaller 1st block amplitude. 1H amplitude in the 1st block of WD SS-VEP was significantly greater than in HV and habituated in successive blocks, contrasting with an amplitude increase in HV. Both the interictal TR-VEP and SS-VEP abnormalities normalized during an attack. There was no significant between group difference in the PW 2H amplitude and its attenuation. When data of HV and migraine patients were combined, the habituation slope of WD-VEP 1H was negatively correlated with that of TR-VEP N1-P1 and with number of days since the last migraine attack.ConclusionThese results are in favour of a migraine cycle-dependent imbalance between excitation and inhibition in the visual cortex. We hypothesize that an interictal hypoactivity of monaminergic pathways may cause a functional disconnection of the thalamus in migraine leading to an abnormal intracortical short-range lateral inhibition that could contribute to the habituation deficit observed during stimulus repetition.

【 授权许可】

CC BY   
© Coppola et al.; licensee Springer. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.