Cortical functional correlates of responsiveness to short-lasting preventive intervention with ketogenic diet in migraine: a multimodal evoked potentials study

The Journal of Headache and Pain

Research Article

Giulio Sirianni¹  Mariano Serrao²  Davide Di Lenola²  Martina Bracaglia²  Francesco Pierelli³  Gianluca Coppola⁴  Vincenzo Parisi⁴  Giorgio Di Lorenzo⁵  Cherubino Di Lorenzo⁶  Paolo Rossi⁷  Maurizio Evangelista⁸ 

[1] Delle Medical Center, Wellness and Dietary Medicine, Rome, Italy;Department of Medico-Surgical Sciences and Biotechnologies, “Sapienza” University of Rome Polo Pontino, Latina, Italy;Department of Medico-Surgical Sciences and Biotechnologies, “Sapienza” University of Rome Polo Pontino, Latina, Italy;INM Neuromed IRCCS, Pozzilli, (IS), Italy;Department of Neurophysiology of Vision and Neurophthalmology, G. B. Bietti Foundation-IRCCS, Rome, Italy;Department of Systems Medicine, University of Rome “Tor Vergata”, Laboratory of Psychophysiology, Rome, Italy;Don Carlo Gnocchi Onlus Foundation, Milan, Italy;INI, Headache Clinic, Grottaferrata, (RM), Italy;Istituto di Anestesiologia, Rianimazione e Terapia del Dolore, Università Cattolica del Sacro Cuore/CIC, Rome, Italy;

关键词: Ketogenesis;    Diet;    Habituation;    Migraine;    Visual-evoked potentials;    Somatosensory-evoked potentials;   

DOI  :  10.1186/s10194-016-0650-9

 received in 2016-03-23, accepted in 2016-05-27,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundHere, we aim to identify cortical electrofunctional correlates of responsiveness to short-lasting preventiveintervention with ketogenic diet (KD) in migraine.MethodsEighteen interictal migraineurs underwent visual (VEPs) and median nerve somatosensory (SSEPs) evokedpotentials before and after 1 month of KD during ketogenesis. We measured VEPs N1-P1 and SSEPs N20-P25 amplitudes respectively in six and in two sequential blocks of 100 sweeps as well as habituation as theslope of the linear regression between block 1 to 6 for VEPs or between 1 to 2 for SSEPs.ResultsAfter 1-month of KD, a significant reduction in the mean attack frequency and duration was observed (all P< 0.001). The KD did not change the 1st SSEP and VEP block of responses, but significantly inducednormalization of the interictally reduced VEPs and SSEPs (all p < 0.01) habituation during the subsequentblocks.ConclusionsKD could restore normal EPs habituation curves during stimulus repetition without significantly changing theearly amplitude responses. Thus, we hypothesize that KD acts on habituation regulating the balancebetween excitation and inhibition at the cortical level.

【 授权许可】

CC BY   
© The Author(s). 2016

【 图 表 】

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