Lack of cold pressor test-induced effect on visual-evoked potentials in migraine

The Journal of Headache and Pain

Original

Alessia Alibardi¹  Manuela Gorini¹  Antonio Curr๠ Gianluca Coppola²  Vincenzo Parisi³  Elisa Porretta⁴  Cherubino Di Lorenzo⁴  Mariano Serrao⁵  Francesco Pierelli⁵ 

[1] Department of Neurological Sciences, Ospedale A. Fiorini-Polo Pontino, “Sapienza” University, Rome, Italy;Department of Neurophysiology of Vision and Neurophthalmology, G. B. Bietti Eye Foundation, IRCCS, Via Livenza 3, 00198, Rome, Italy;Department of Neurophysiology of Vision and Neurophthalmology, G. B. Bietti Eye Foundation, IRCCS, Via Livenza 3, 00198, Rome, Italy;University of Rome “Campus Biomedico”, Rome, Italy;University Centre for Adaptive Disorders and Headache (UCADH), “Sapienza” University of Rome, Polo Pontino, ICOT, Latina, Italy;University Centre for Adaptive Disorders and Headache (UCADH), “Sapienza” University of Rome, Polo Pontino, ICOT, Latina, Italy;IRCCS Neuromed, Pozzilli (IS), Italy;

关键词: Migraine;    Cold pressor test;    Visual-evoked potentials;    Habituation;    Brainstem;    Thalamo-cortical activity;   

DOI  :  10.1007/s10194-009-0177-4

 received in 2009-10-21, accepted in 2009-11-19,  发布年份 2009

来源: Springer

【 摘 要 】

In patients with migraine, the various sensory stimulation modalities, including visual stimuli, invariably fail to elicit the normal response habituation. Whether this lack of habituation depends on abnormal activity in the sub-cortical structures responsible for processing incoming information as well as nociception and antinociception or on abnormal cortical excitability per se remains debateable. To find out whether inducing tonic pain in the hand by cold pressure test (CPT) alters the lack of visual-evoked potential (VEP) habituation in migraineurs without aura studied between attacks we recorded VEPs in 19 healthy subjects and in 12 migraine patients during four experimental conditions: baseline; no-pain (hand held in warm water, 25°C); pain (hand held in cold water, 2–4°C); and after-effects. We measured P100 amplitudes from six blocks of 100 sweeps, and assessed habituation from amplitude changes between the six sequential blocks. In healthy subjects, the CPT decreased block 1 VEP amplitude and abolished the normal VEP habituation (amplitude decrease to repeated stimulation) in patients with migraine studied between attacks; it left block 1 VEP amplitude and abnormal VEP habituation unchanged. These findings suggest that the interictal cortical dysfunction induced by migraine prevents the cortical changes induced by tonic painful stimulation both during pain and after pain ends. Because such cortical changes presumably reflect plasticity mechanisms in the stimulated cortex, our study suggests altered plasticity of sensory cortices in migraine. Whether this abnormality reflects abnormal functional activity in the subcortical structures subserving tonic pain activation remains conjectural.

【 授权许可】

Unknown   
© Springer-Verlag 2009