Migraine and risk of hemorrhagic stroke: a study based on data from general practice

The Journal of Headache and Pain

Short Report

Antonio González-Pérez¹  Messoud Ashina²  David Gaist³  Luis Alberto García Rodríguez⁴ 

[1] Andalusian Bioinformatics Research Center (CAEBi), Seville, Spain;Department of Neurology & the Danish Headache Center, Glostrup University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;Department of Neurology, Odense University Hospital and Institute of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Sdr Boulevard 29, 5000, Odense, Denmark;Spanish Centre for Pharmacoepidemiologic Research (CEIFE), Madrid, Spain;

关键词: Intracerebral hemorrhage;    Subarachnoidal hemorrhage;    Risk factors;    Migraine;   

DOI  :  10.1186/1129-2377-15-74

 received in 2014-10-06, accepted in 2014-11-04,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundWe investigated the association between hemorrhagic stroke and migraine using data from The Health Improvement Network database.FindingsWe ascertained 1,797 incident cases of intracerebral hemorrhage (ICH) and 1,340 of subarachnoid hemorrhage (SAH). Density-based sampling was used to select 10,000 controls free from hemorrhagic stroke. Using unconditional logistic regression models, we calculated the risk of hemorrhagic stroke associated with migraine, adjusting for age, sex, calendar year, alcohol, body mass index, hypertension, previous cerebrovascular disease, oral contraceptive use, and health services utilization.The risk (odds ratio [OR]) of ICH among migraineurs was 1.2 (95% confidence interval [CI] 0.9–1.5), and of SAH was (1.2, 95% CI 0.9–1.5). The association with ICH was stronger for migraine diagnosed ≥20 years prior to ICH (OR 1.6, 95% CI 1.0–2.4), but not with SAH (OR 1.1, 95% CI 0.6–2.1). In analyses stratified by migraine type and gender, the OR of ICH in women with migraine with aura was 1.7 (95% CI 0.9–3.4) and the corresponding OR of SAH in women was 1.2 (95% CI 0.6–2.3).ConclusionNo clear increased risk of ICH or SAH was observed in migraineurs.

【 授权许可】

CC BY   
© Gaist et al.; licensee Springer. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.