Spontaneous intracerebral hemorrhage in CADASIL

The Journal of Headache and Pain

Case Report

Suiqiang Zhu¹  Lifei Lian¹  Qiming Liang¹  Feng Xu¹  Zheng Xue¹  Xiaoyan Liu¹  Huicong Kang¹  Dujuan Li² 

[1] Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, 430030, Wuhan, Hubei, P.R. China;Department of Pathology, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, No.7 Weiwu Road, 450003, Zhengzhou, Henan, P.R. China;

关键词: Migraine;    CADASIL;    Intracerebral hemorrhage;    NOTCH;    Microbleeds;   

DOI  :  10.1186/1129-2377-14-98

 received in 2013-11-12, accepted in 2013-12-12,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundCerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare hereditary small vascular disease and its mainly clinical manifestations are ischemic events. Spontaneous intracerebral hemorrhage (ICH) involvement in patients with CADASIL is extremely uncommon.Case reportA 46-year-old normotensive Chinese man developed a large hematoma in the left basal ganglia after he was diagnosed with CADASIL 2 months ago, the patient did not take any antithrombotics. Susceptibility weighted imaging at pre-ICH showed multiple cerebral microbleeds (CMBs) in the bilateral basal ganglia. He experienced migraine at about 10 months post-ICH. To our knowledge, this is the first report of ICH in CADASIL patients with Arg90Cys mutation in exon 3.Discussion and conclusionsICH should be considered when evaluating new attacks in CADASIL patients. Thus, MRI screening for CMBs might be helpful in predicting the risk of ICH and guiding antithrombotic therapy. In addition, strict control of hypertension and cautious use of antithrombotics may be important in this context.

【 授权许可】

Unknown   
© Lian et al.; licensee Springer. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.