Migraine headache: a review of the molecular genetics of a common disorder

The Journal of Headache and Pain

Tutorial

Cherubino Di Lorenzo¹  Gaetano S. Grieco²  Filippo M. Santorelli³ 

[1] Don Carlo Gnocchi Onlus Foundation, Rome, Italy;Laboratory of Neurogenetics, C. Mondino National Institute of Neurology Foundation, IRCCS, Pavia, Italy;Molecular Medicine and Neurodegenerative Diseases-IRCCS Stella Maris, Pisa, Italy;Child Neurology, University of Pisa, Pisa, Italy;Molecular Medicine, IRCCS Stella Maris, via dei Giacinti 2, 56128, Calambrone, Pisa, Italy;

关键词: Migraine;    Genetics;    Familial hemiplegic migraine (FHM);    CADASIL;    MELAS;    Pharmacogenomics;   

DOI  :  10.1007/s10194-012-0478-x

 received in 2012-06-22, accepted in 2012-08-18,  发布年份 2012

来源: Springer

【 摘 要 】

This tutorial summarises the state-of-the-art on migraine genetics and looks at the possible future direction of this field of research. The view of migraine as a genetic disorder, initially based on epidemiological observations of transmission of the condition within families, was subsequently confirmed by the identification of monogenic forms of “syndromic” migraine, such as familial hemiplegic migraine. We are currently witnessing a change in the way genetic analysis is used in migraine research: rather than studying modalities of inheritance in non-monogenic forms of migraine and in the persistent modalities of migraine headache, researchers are now tending to focus on the search for genetic markers of dysfunction in biological systems. One example of the evolution of migraine genetic research is provided by the recent efforts to shed light on the pharmacogenomic mechanisms of drug response in migraineurs. In addition, novel molecular approaches about to be introduced are expected to further increase knowledge on this topic and improve patient management.

【 授权许可】

CC BY   
© The Author(s) 2012