Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis

Frontiers in Chemistry

Chemistry

Michael J. Oldham¹  David K. Cook¹  Austin L. Bates¹  Cameron R. Smith¹  I. Gene Gillman¹  Jiaming Wang¹  Patrick C. Bailey¹  Sifat Ullah¹  Alexander S. C. Pennington¹  Lena N. Jeong¹  J. Brian Jameson² 

[1] Juul Labs, Inc., Washington, DC, United States;null;

关键词: ENDS;    nicotine;    tobacco;    carbonyls;    formaldehyde;    metals;    nickel;    glycidol;   

DOI  :  10.3389/fchem.2023.1223967

 received in 2023-05-16, accepted in 2023-08-18,  发布年份 2023

来源: Frontiers

【 摘 要 】

Literature reports the chemical constituent yields of electronic nicotine delivery systems (ENDS) aerosol collected using a range of aerosol collection strategies. The number of puffs to deplete an ENDS product varies widely, but collections often consist of data from the first 50–100 puffs. However, it is not clear whether these discrete puff blocks are representative of constituent yields over the life of a pod. We aimed to assess the effect of differing aerosol collection strategies on reported yields for select chemical constituents in the aerosol of closed pod-based ENDS products. Constituents analyzed were chosen to reflect important classes of compounds from the Final Premarket Tobacco Product Application Guidance. Yields were normalized to total device mass loss (DML). Collection strategies that consisted of partial pod collection were valid for determining yields of constituents whose DML normalized yields were consistent for the duration of pod life. These included primary aerosol constituents, such as propylene glycol, glycerol, and nicotine, and whole pod yields could be determined from initial puff blocks. However, changes were observed in the yields of some metals, some carbonyl compounds, and glycidol over pod life in a chemical constituent and product dependent manner. These results suggest that collection strategies consisting of initial puff block collections require validation per chemical constituent/product and are not appropriate for chemical constituents with variable yields over pod life. Whole pod collection increased sensitivity and accuracy in determining metal, carbonyl, and glycidol yields compared to puff block-based collection methodologies for all products tested.

【 授权许可】

Unknown   
Copyright © 2023 Jameson, Wang, Bailey, Oldham, Smith, Jeong, Cook, Bates, Ullah, Pennington and Gillman.