| Harm Reduction Journal | |
| Cannabis and tobacco smoke are not equally carcinogenic | |
| Robert Melamede1  | |
| [1] Biology Department, 1420 Austin Bluffs Parkway, University of Colorado, Colorado Springs, 80918, USA | |
| 关键词: nicotine; carcinogens; cannabinoids; smoke; cancer; tobacco; marijuana; | |
| Others : 821548 DOI : 10.1186/1477-7517-2-21 |
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| received in 2004-11-30, accepted in 2005-10-18, 发布年份 2005 | |
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【 摘 要 】
More people are using the cannabis plant as modern basic and clinical science reaffirms and extends its medicinal uses. Concomitantly, concern and opposition to smoked medicine has occurred, in part due to the known carcinogenic consequences of smoking tobacco. Are these reactions justified? While chemically very similar, there are fundamental differences in the pharmacological properties between cannabis and tobacco smoke. Cannabis smoke contains cannabinoids whereas tobacco smoke contains nicotine. Available scientific data, that examines the carcinogenic properties of inhaling smoke and its biological consequences, suggests reasons why tobacco smoke, but not cannabis smoke, may result in lung cancer.
【 授权许可】
2005 Melamede; licensee BioMed Central Ltd.
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| 20140712080425139.pdf | 243KB |
【 参考文献 】
- [1]Khurana S, Batra V, Patkar AA, Leone FT: Twenty-first century tobacco use: it is not just a risk factor anymore. Respir Med 2003, 97(4):295-301.
- [2]Thun MJ, Henley SJ, Calle EE: Tobacco use and cancer: an epidemiologic perspective for geneticists. Oncogene 2002, 21(48):7307-7325.
- [3]Alavanja MC: Biologic damage resulting from exposure to tobacco smoke and from radon: implication for preventive interventions. Oncogene 2002, 21(48):7365-7375.
- [4]Novotny M, Merli F, Weisler D, Fencl M, Saeed T: Fractionation and capillary gas chromatographic-mass spectrometric characterization of the neutral components in marijuana and tobacco smoke condensates. J Chromatogr 1982, 238:141-150.
- [5]Tashkin DR, Baldwin GC, Sarafian T, Dubinett S, Roth MD: Respiratory and immunologic consequences of marijuana smoking. J Clin Pharmacol 2002, 42(11 Suppl):71S-81S.
- [6]Sidney S, Beck JE, Tekawa IS, Quesenberry CP, Friedman GD: Marijuana use and mortality. Am J Public Health 1997, 87:585-590.
- [7]Hashibe M, Straif K, Tashkin DP, Morgenstern H, Greenland S, Zhang ZF: Epidemiologic review of marijuana use and cancer risk. Alcohol 2005, 35:265-275.
- [8]Tashkin DP: Smoked marijuana as a cause of lung injury. Monaldi Arch Chest Dis 2005, 63:93-100.
- [9]Munson AE, Harris LS, Friedman MA, Dewey WL, Carchman RA: Antineoplastic activity of cannabinoids. J Natl Cancer Inst 1975, 55:597-602.
- [10]Sanchez C, de Ceballos ML, del Pulgar TG, Rueda D, Corbacho C, Velasco G, Galve-Roperh I, Huffman JW, Ramon y, Cajal S, Guzman M: Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor. Cancer Res 2001, 61:5784-5789.
- [11]McKallip RJ, Lombard C, Fisher M, Martin BR, Ryu S, Grant S, Nagarkatti PS, Nagarkatti M: Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease. Blood 2002, 100:627-634.
- [12]Sanchez C, Galve-Roperh I, Canova C, Brachet P, Guzman M: Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells. FEBS Lett 1998, 436:6-10.
- [13]Casanova ML, Blazquez C, Martinez-Palacio J, Villanueva C, Fernandez-Acenero MJ, Huffman JW, Jorcano JL, Guzman M: Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. J Clin Invest 2003, 111:43-50.
- [14]Sarker KP, Obara S, Nakata M, Kitajima I, Maruyama I: Anandamide induces apoptosis of PC-12 cells: involvement of superoxide and caspase-3. FEBS Lett 2000, 472:39-44.
- [15]Hart S, Fischer OM, Ullrich A: Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor. Cancer Res 2004, 64:1943-1950.
- [16]Godschalk R, Nair J, van Schooten FJ, Risch A, Drings P, Kayser K, Dienemann H, Bartsch H: Comparison of multiple DNA adduct types in tumor adjacent human lung tissue: effect of cigarette smoking. Carcinogenesis 2002, 23:2081-2086.
- [17]Watson SJ, Benson JAJ, Joy JE: Marijuana and medicine: assessing the science base: a summary of the 1999 Institute of Medicine report. Arch Gen Psychiatry 2000, 57(6):547-552.
- [18]Wu TC, Tashkin DP, Djahed B, Rose JE: Pulmonary hazards of smoking marijuana as compared with tobacco. N Engl J Med 1988, 318:347-351.
- [19]Grotenhermen F: Pharmacokinetics and pharmacodynamics of cannabinoids. Clin Pharmacokinet 2003, 42(4):327-360.
- [20]Nebert DW, Gonzalez FJ: P450 genes: structure, evolution, and regulation. Annu Rev Biochem 1987, 56:945-993.
- [21]Hecht SS, Carmella SG, Murphy SE, Foiles PG, Chung FL: Carcinogen biomarkers related to smoking and upper aerodigestive tract cancer. J Cell Biochem Suppl 1993, 17F:27-35.
- [22]Tretyakova N, Matter B, Jones R, Shallop A: Formation of benzo[a]pyrene diol epoxide-DNA adducts at specific guanines within K-ras and p53 gene sequences: stable isotope-labeling mass spectrometry approach. Biochemistry 2002, 41:9535-9544.
- [23]Roth MD, Marques-Magallanes JA, Yuan M, Sun W, Tashkin DP, Hankinson O: Induction and regulation of the carcinogen-metabolizing enzyme CYP1A1 by marijuana smoke and delta (9)-tetrahydrocannabinol. Am J Respir Cell Mol Biol 2001, 24:339-344.
- [24]Price RJ, Renwick AB, Walters DG, Young PJ, Lake BG: Metabolism of nicotine and induction of CYP1A forms in precision-cut rat liver and lung slices. Toxicol In Vitro 2004, 18:179-185.
- [25]Nebert DW, Russell DW: Clinical importance of the cytochromes P450. Lancet 2002, 360(9340):1155-1162.
- [26]Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, Gibson D, Mandelbaum A, Etinger A, Mechoulam R: Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 1992, 258:1946-1949.
- [27]West KA, Brognard J, Clark AS, Linnoila IR, Yang X, Swain SM, Harris C, Belinsky S, Dennis PA: Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. J Clin Invest 2003, 111:81-90.
- [28]Woo RA, Poon RY: Cyclin-Dependent Kinases and S Phase Control in Mammalian Cells. Cell Cycle 2003, 2:316-324.
- [29]Bockaert J, Pin JP: Molecular tinkering of G protein-coupled receptors: an evolutionary success. EMBO J 1999, 18(7):1723-1729.
- [30]Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA, Felder CC, Herkenham M, Mackie K, Martin BR, Mechoulam R, Pertwee RG: International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev 2002, 54(2):161-202.
- [31]Itier V, Bertrand D: Neuronal nicotinic receptors: from protein structure to function. FEBS Lett 2001, 504(3):118-125.
- [32]Gomez del Pulgar T, Velasco G, Guzman M: The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt. Biochem J 2000, 347:369-373.
- [33]Minna JD: Nicotine exposure and bronchial epithelial cell nicotinic acetylcholine receptor expression in the pathogenesis of lung cancer. J Clin Invest 2003, 111(1):31-33.
- [34]Panikashvili D, Simeonidou C, Ben-Shabat S, Hanus L, Breuer A, Mechoulam R, Shohami E: An endogenous cannabinoid (2-AG) is neuroprotective after brain injury. Nature 2001, 413:527-531.
- [35]Leker RR, Shohami E, Abramsky O, Ovadia H: Dexanabinol; a novel neuroprotective drug in experimental focal cerebral ischemia. J Neurol Sci 1999, 162:114-119.
- [36]Iuvone T, Esposito G, Esposito R, Santamaria R, Di Rosa M, Izzo AA: Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells. J Neurochem 2004, 89:134-141.
- [37]Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, Kume T, Akaike A: alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity. J Biol Chem 2001, 276:13541-13546.
- [38]Heeschen C, Jang JJ, Weis M, Pathak A, Kaji S, Hu RS, Tsao PS, Johnson FL, Cooke JP: Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis. Nat Med 2001, 7:833-839.
- [39]Galve-Roperh I, Sanchez C, Cortes ML, del Pulgar TG, Izquierdo M, Guzman M: Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Nat Med 2000, 6:313-319.
- [40]Blazquez C, Gonzalez-Feria L, Alvarez L, Haro A, Casanova ML, Guzman M: Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. Cancer Res 2004, 64:5617-5623.
- [41]Sarafian TA, Magallanes JA, Shau H, Tashkin D, Roth MD: Oxidative stress produced by marijuana smoke. An adverse effect enhanced by cannabinoids. Am J Respir Cell Mol Biol 1999, 20:1286-1293.
- [42]Chung HY, Kim HJ, Kim JW, Yu BP: The inflammation hypothesis of aging: molecular modulation by calorie restriction. Ann N Y Acad Sci 2001, 928:327-335.
- [43]Raha S, Robinson BH: Mitochondria, oxygen free radicals, and apoptosis. Am J Med Genet 2001, 106:62-70.
- [44]Halliwell B: Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment. Drugs Aging 2001, 18:685-716.
- [45]Drew B, Leeuwenburgh C: Aging and the role of reactive nitrogen species. Ann N Y Acad Sci 2002, 959:66-81.
- [46]Yuan M, Kiertscher SM, Cheng Q, Zoumalan R, Tashkin DP, Roth MD: Delta 9-Tetrahydrocannabinol regulates Th1/Th2 cytokine balance in activated human T cells. J Neuroimmunol 2002, 133:124-131.
- [47]Mirken B: Vaporizers for medical marijuana. Aids Treat News No 327 1999; Sect. 1, 5.
- [48]Gieringer D, St Laqurent J, Goodrich S: Cannabis Vaporizer Combines Efficient Delivery of THC with Effective Suppression of Pyrolytic Compounds. In Journal of Cannabis Therapeutics. 4th edition. Edited by Dr. Ethan Russo. Binghamton, New York: Haworth Press; 2004:7-27.
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