Epidemiology of human papillomavirus-associated anogenital cancers in Granada: a three-decade population-based study

Frontiers in Public Health

Public Health

Jose Juan Jiménez-Moleón¹  Miguel Rodríguez-Barranco²  Nicolás Francisco Fernández-Martínez²  Dafina Petrova²  María-José Sánchez³  Pablo Dabán-López⁴  Javier Gutierrez⁴ 

[1] Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain;CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain;Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain;Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain;Escuela Andaluza de Salud Pública (EASP), Granada, Spain;CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain;Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain;Escuela Andaluza de Salud Pública (EASP), Granada, Spain;CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain;Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain;Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario San Cecilio, Granada, Spain;

关键词: human papillomavirus;    anogenital cancer;    epidemiology;    incidence;    mortality;    survival;    cervical cancer;    time trends;   

DOI  :  10.3389/fpubh.2023.1205170

 received in 2023-04-13, accepted in 2023-08-29,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionHPV infection is a common risk factor for all anogenital cancers. However, there are important differences in the epidemiology of anogenital cancers and these have not been compared considering diverse epidemiological indicators over a long period of time. To fill this gap, we investigated incidence, mortality, and survival trends of anogenital cancers over a period of three decades.MethodsWe conducted an observational registry-based study using data from the population-based cancer registry of Granada in southern Spain. We collected data on all incident cases of anogenital cancer (cervical, anal, penile, vulvar, and vaginal cancer) diagnosed between 1985 and 2017. We calculated crude and age-standardized incidence and mortality rates, and 1, 3, and 5-year overall and net survival. We further conducted time-trend analysis calculating annual percent changes (APC) for each cancer site.ResultsThe incidence of anogenital cancers decreased slightly during the past 30 years, with the exception of vulvar cancer, where a slight increase was observed. Mortality decreased significantly for cervical cancer over the study period but increased non-significantly for the remaining cancer sites. Survival rates were similar to those reported in comparable countries and increased for cervical and vulvar cancer.DiscussionCervical cancer was the greatest contributor to the burden of anogenital cancers and showed a marked improvement in all indicators in comparison to the remaining cancer sites.

【 授权许可】

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Copyright © 2023 Dabán-López, Fernández-Martínez, Petrova, Rodríguez-Barranco, Jiménez-Moleón, Gutierrez and Sánchez.